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Title: Detection and molecular characterisation of zoonotic enteric pathogens in animals and humans in southern India
Researcher: Priya R
Guide(s): Deva Prasanna Rajan
Keywords: animals
Detection and molecular characterisation
southern India
zoonotic enteric pathogens
University: The Tamil Nadu Dr. M.G.R. Medical University
Completed Date: 2011
Abstract: Diarrhea remains the second leading infectious cause of childhood death worldwide, despite the improved safety of food, water and sanitation and the aggressive promotion of noninvasive interventions and prevention strategies, accounting for approximately 1.8 million annual deaths in children under 5 years of age. The majority of these diarrheal deaths (1.46 million, 76%) occur in the developing countries of Africa and south-east Asia. It is estimated that around 23% of Indian children die before the age of five due to diarrhea and the attack rates sometimes reach six or more episodes per child per year. In addition to the mortality and morbidity associated with diarrhea as a dehydrating illness, chronic and recurrent diarrhea in early childhood has been shown to have long-term effects such as stunting and developmental delays caused by poor nutrient absorption. In this study, we report the distribution of rotavirus genotypes in human and animal diarrhea. The distribution of genotypes in animals showed G6 infections as the predominant cause of symptomatic rotavirus infection followed by G2, while in children G1, G2 and G9 strains were common. With G2 infections identified in animals, reverse zoonotic transmission should be considered since this genotype is predominantly associated with infection in humans. G10P a bovine human reassortant found in asymptomatic infections in children and in neonates, was not identified in animals indicating that the strain is now well adapted to humans. newline
Pagination: 202
Appears in Departments:Department of Medical

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02_table_of_contents.pdf11.06 kBAdobe PDFView/Open
03_acknowledgements.pdf63.17 kBAdobe PDFView/Open
04_list_of_abbreviations.pdf76.09 kBAdobe PDFView/Open
05_chapter1.pdf80.1 kBAdobe PDFView/Open
06_chapter2.pdf214.38 kBAdobe PDFView/Open
07_chapter3.pdf60.48 kBAdobe PDFView/Open
08_chapter4.pdf139.29 kBAdobe PDFView/Open
09_chapter5.pdf931.67 kBAdobe PDFView/Open
10_chapter6.pdf70.16 kBAdobe PDFView/Open
11_bibliography.pdf188.26 kBAdobe PDFView/Open
12_appendices.pdf92.02 kBAdobe PDFView/Open
13_publications.pdf1.34 MBAdobe PDFView/Open

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