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Title: An immunoepidemiological study on the effect of neonatal BCG vaccination on intracellular killing of Mycobacterium tuberculosis by human macrophages
Researcher: Mathan Periasamy C
Guide(s): Manjula Datta
Keywords: human macrophages
immunoepidemiological study
intracellular killing
Mycobacterium tuberculosis
neonatal BCG vaccination
University: The Tamil Nadu Dr. M.G.R. Medical University
Completed Date: 2009
Abstract: Tuberculosis (TB) was the first disease to be declared a global emergency by the World Health Organization in 1993, an honor not even enjoyed by small pox. It is an infectious disease caused by Mycobacterium tuberculosis mainly and sometimes other closely related Mycobacterium strains M. africanum and M. bovis which are commonly known as the TB-complex. The pathogen M. tuberculosis infects approximately 32% of the world human population and about 10% of the infected develop the disease. Tuberculosis continues to be a major worldwide health problem and is the leading killer of youth and adults in developing countries, being responsible for more deaths than any other single infectious organism. Several prominent persons like John Keats, Leo Tolstoy, Alexander Graham Bell and Florence Nightingale have died of tuberculosis. Global prevalence of the disease increased greatly following the industrial revolution, with rapid urbanization and overcrowding. HIV epidemic and the appearance of multidrug-resistant strains of M. tuberculosis (MDR-TB) have contributed significantly to the resurgence of TB. The present study has evaluated the association of certain common risk factors with the tuberculin response by logistic regression analysis using tuberculin response result as the dependent variable. The association was expressed in OR (Odds ratio) with 95% confident intervals. Out of 173 tested study subjects, 53 of them were reactors. The risk factors included in the questionnaire and their association with the tuberculin reactivity is shown in table-7. The questionnaire included The status of BCG scar as a question to associate BCG scar with tuberculin response. Out of 74 subjects with scar, only 29 of them were reactors (OR 1.7; 95% CI 0.8- 3.4). The impact was not statistically significant. newline
Pagination: 207
Appears in Departments:Department of Medical

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02_certificate.pdf10.3 kBAdobe PDFView/Open
03_preliminary pages.pdf37.41 kBAdobe PDFView/Open
04_chapter1.pdf17.85 kBAdobe PDFView/Open
05_chapter2.pdf141.07 kBAdobe PDFView/Open
06_chapter3.pdf21.26 kBAdobe PDFView/Open
07_chapter4.pdf16.46 kBAdobe PDFView/Open
08_chapter5.pdf117.62 kBAdobe PDFView/Open
09_chapter6.pdf516 kBAdobe PDFView/Open
10_chapter7.pdf44.94 kBAdobe PDFView/Open
11_chapter8.pdf19.02 kBAdobe PDFView/Open
12_chapter9.pdf15.14 kBAdobe PDFView/Open
13_chapter10.pdf14.78 kBAdobe PDFView/Open
14_references.pdf81.18 kBAdobe PDFView/Open
15_annexures.pdf1.31 MBAdobe PDFView/Open

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