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Title: Synthesis and In Vitro Pharmacological Evaluation of Indoles and Alkynyl substituted Thieno Pyrimidines, Indazoles and Pyrazoles
Researcher: Gorja, Dhilli Rao
Guide(s): Mukkanti, K
Pal, Manojit
Keywords: Evaluation
Upload Date: 17-Jun-2014
University: Jawaharlal Nehru Technological University, Hyderabad
Completed Date: 2013
Abstract: Investigations embodied in this thesis entitled Synthesis and In vitro newlinePharmacological Evaluation of Indoles and Alkynyl Substituted Thieno pyrimidines, Indazoles and Pyrazoles have been presented in five chapters as follow: newlineChapter 1: Pd/C mediated alkynylation of N-heterocycles This chapter started with the importance of Sonogashira reactions in C C newlinebond-formation and its wide applications in synthetic and organometallic chemistry. This chapter also deals with the importance, use and versatility of Pd/C catalyst and its advantages over other Pd-catalysts. Pd/C is a cheap and air stable catalyst which can be easily recovered from the reaction newlinemixture and is recyclable. The plausible mechanism associated with the Pd/C mediated coupling reactions is also discussed. The later part of this chapter is based on the various reaction approaches utilizing Pd/C catalyst for the synthesis of alkynylated N-heterocycles.
Pagination: 230 p.
Appears in Departments:Department of Chemistry

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01_title.pdfAttached File147.02 kBAdobe PDFView/Open
02_certificate.pdf76.14 kBAdobe PDFView/Open
03_declaration.pdf63.81 kBAdobe PDFView/Open
04_acknowledgement.pdf115.84 kBAdobe PDFView/Open
05_abstract.pdf116.15 kBAdobe PDFView/Open
06_contents.pdf115.5 kBAdobe PDFView/Open
07_chatper 1.pdf240.89 kBAdobe PDFView/Open
08_chapter 2.pdf4.05 MBAdobe PDFView/Open
09-chapter 3.pdf2.73 MBAdobe PDFView/Open
10_chapter 4.pdf1.5 MBAdobe PDFView/Open
11_chapter 5.pdf1.32 MBAdobe PDFView/Open

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