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Title: Effect of selected nanoflavonoid against lead induced hepatic damage in experimental animals
Researcher: Sridevi Sangeetha K.S.
Guide(s): Umamaheswari S.
Keywords: Antioxidant
Oxidative stress
University: Sri Ramachandra University
Completed Date: 10/01/2018
Abstract: Contamination of heavy metals in the environment is a major global concern because of toxicity and threat to the human life and ecosystem One of the earliest metals discovered by the human population is Lead It is a well known fact that the usage of lead and its cause of deleterious effects are exclusively due to man made sources Hence it has become a continuous serious threat to the human health Enormous no of evidences have shown that lead causes oxidative stress by inducing the generation of reactive oxygen species and weakening the antioxidant defense mechanism of cell The clinical importance of the herbal drugs has recently received considerable attention Their role is limited to act as an antioxidant and to provide better recovery in the altered biochemical variables Flavonoids are the secondary metabolites of plant with significant antioxidant properties So it may have beneficial effect against lead induced hepatic damage The flavonoid have poor solubility in water this limits the bioavailability of the compound Hence attempt has been taken to develop nanoflavonoids using natural polymers like chitosan The hepatoprotective effect of the flavonoid and the nanoflavonoid was determined by carrying out cell viability assay using chang cell ine Then the effect of flavonoid and the nanoflavonoid on lead induced hepatic damage was studied in male wistar rats The parameters like body weight organ weight urine analysis hematological profile serum biochemical profile blood lead marker enzyme hepatic and renal antioxidant parameters lead level in major organs were studied The effect of Diosmin and Diosmin Encapsulated Chitosan Nanoparticle was compared with standard hepatoprotective drug silymarin Diosmin and Diosmin Encapsulated Chitosan Nanoparticle showed significant hepatoprotection when compared with standard silymarin which further strengthened the concept of this novel formulation newline
Pagination: 1- 206
Appears in Departments:College of Allied Health & Sciences

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