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Title: Method Development for Impurities in some Multicomponent Dosage Forms and Cardiovascular Drugs
Researcher: Aparna, Ponnala
Guide(s): Thomas, K M
Mukkanti, K
Keywords: Cardiovascular
Upload Date: 30-May-2014
University: Jawaharlal Nehru Technological University, Hyderabad
Completed Date: 2013
Abstract: Chapter-1 is about general introduction of impurities and method development. newlineChapter-2 describes about an unknown impurity formed in 50°C stability samples at 3 months in Lamivudine, Zidovudine and Nevirapine tablets for oral suspension which was detected by the new HPLC method. This degradation product was isolated by using newlinepreparative chromatography. The chemical structure of the degradant was elucidated by MS, 1H-NMR, 13C-NMR, DEPT and IR. The data newlineindicated that the structure as 1-[5-Hydroxymethyl-4-(5-methyl-2,3- dihydro-[1,2,3]triazole-1yl)-tetrahydro-furan-2-yl]-5-methyl-1Hpyrimidine- 2,4-(1H,3H)-dione. The mechanism of formation of this newlineimpurity is described in detail
Pagination: 141 p.
Appears in Departments:Department of Chemistry

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01_title.pdfAttached File6.7 kBAdobe PDFView/Open
02_abstract.pdf77.67 kBAdobe PDFView/Open
03_chapter 1.pdf597.34 kBAdobe PDFView/Open
04_chapter 2.pdf517.18 kBAdobe PDFView/Open
05_chapter 3.pdf273.11 kBAdobe PDFView/Open
06_chapter 4.pdf301.54 kBAdobe PDFView/Open
07_chapter 5.pdf271.43 kBAdobe PDFView/Open
08_chapter 6.pdf347.24 kBAdobe PDFView/Open

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