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Title: Synthesis and Biological Activity of Benzodiazepins, Dihydropyrimidinones, Quionoxalin-Amines and their derivatives
Researcher: Shobha, Denthabhakthuni
Guide(s): Mukkanti , K
Keywords: Benzodiazepins
Upload Date: 20-May-2014
University: Jawaharlal Nehru Technological University, Hyderabad
Completed Date: 2012
Abstract: The thesis entitled Synthesis and Biological Activity of Benzodiazepines, Dihydropyrimidinones, Quinoxalin-amines and newlineTheir Derivatives is classified in to seven chapters. The thesis title explains the objective, which gives the detailed study of synthesis, characterization and biological activity of nitrogen containing heterocyclic compounds such as Benzodiazepines, Dihydropyrimidinones, Quinoxalin-amines and their derivatives. Chapter-I presents an newlineintroduction to N-containing heterocyclic compounds and their pharmacological importance and literature survey on the present existing synthetic methods. Chapter-II describes experimental details newlineof synthesis, characterization and biological activity of N-containing heterocyclic compounds. Chapter-III deals with the room temperature synthesis of 1,5-benzodiazepines (BDPs) using silica gel supported sulfuric acid and cage type mesoporous aluminosilicate (AlKIT-5) catalysts, which constitute a novel biologically active chloro substituted compounds. Chapter-IV describes the study of synthesis and characterization of 3,4 dihydropyrimidin 2-ones (DHPMs) using newlineDichloro Dicyano Quinone (DDQ) and mesoporous aluminosilicate (AlKIT-5) catalyst with cage type pore structure. Here a new series of newlinebiologically active thio substituted DHPMs are described. Chapter-V deals with the synthesis and characterization of novel 3,4-Dihydroquinoxalin- 2-amine derivatives using p-toulene sulfonic acid (PTSA) and AlKIT-5 catalysts. Chapter-VI describes the anti-neuroinflammatory effect of BDPs, DHPMs and 3,4-dihydroquinoxalin-2-amine derivatives. Chapter-VII deals with the conclusions of the present work.
Pagination: 361 p,
Appears in Departments:Department of Chemistry

Files in This Item:
File Description SizeFormat 
01_title.pdfAttached File29.41 kBAdobe PDFView/Open
02_dedication.pdf35.94 kBAdobe PDFView/Open
03_declaration.pdf58.22 kBAdobe PDFView/Open
04_certificate.pdf65.97 kBAdobe PDFView/Open
05_acknowledgement.pdf67.34 kBAdobe PDFView/Open
06_contents.pdf94.81 kBAdobe PDFView/Open
07_abstract.pdf183.38 kBAdobe PDFView/Open
08_chapter 1.pdf552.94 kBAdobe PDFView/Open
09_chapter 2.pdf121.62 kBAdobe PDFView/Open
10_chatper 3.pdf4.71 MBAdobe PDFView/Open
11_chapter 4.pdf3 MBAdobe PDFView/Open
12_chapter 5.pdf2.59 MBAdobe PDFView/Open
13_chapter 6.pdf304.84 kBAdobe PDFView/Open
14_chapter 7.pdf145.23 kBAdobe PDFView/Open

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