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Title: Analysis of somatic cell mutations at the Glycophorin - a locus in human erythrocytes
Researcher: Maddaly Ravi
Guide(s): Paul, Solomon F D
Keywords: Human Genetics
Human erythrocytes
Upload Date: 26-Feb-2014
University: Sri Ramachandra University
Completed Date: January, 2005
Abstract: Introduction: Dose evaluation of exposed humans to radiation becomes necessary after exposure. Such a dose evaluation can be done by biological dosimetric methods of which increased somatic cell mutant frequencies in exposed individuals can be a reliable index [1]. Biological dosimetry has an important role to play in assessing the cumulative radiation exposure of persons working with radiation and also in estimating the true dose received during accidents involving external and internal exposure. Biodosimetric methods include cytogenetic, immunological and mutational assays [2]. newlineThe need for biodosimetry is essential for caliberating the actual dose received to a biological system where other conventional forms of dosimetry are unavailable. Even in the presence of other dosimetric tools such as Thermo Luminescent Devices newline(TLDs) etc, biological dosimetry gives actual doses apart from an indication of the extent of damage caused by such damages. This becomes all the more important with the current situations such as space programmes and dirty bombs. There are currently many advancing methods for measuring somatic mutations and new opportunities for biological dosimetry of high-risk groups. An evaluation of such mutations becomes all the more important, as such mutations can be possible predictors of cancer risk [3]. Somatic mutations can now be measured in several human genes. The genes currently used include the hemoglobin (Hb) genes on chromosome 11 and 16, the glycophorin A (GPA) gene on chromosome 4, the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene on the Xchromosome, the HLA genes on the chromosome 6 and the T-cell receptor (TCR) genes on chromosomes 7 and 14. Of the various assays for somatic mutations, only GPA and HPRT have been studied sufficiently to have reliable databases.
Pagination: 131p.
Appears in Departments:Department of Human Genetics

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02_certificate & declaration.pdf359.99 kBAdobe PDFView/Open
03_acknoledgements.pdf9.58 kBAdobe PDFView/Open
04_contents.pdf310.72 kBAdobe PDFView/Open
05_abstract.pdf125.67 kBAdobe PDFView/Open
06_chapter 1.pdf1.64 MBAdobe PDFView/Open
07_chapter 2.pdf167.02 kBAdobe PDFView/Open
08_chapter 3.pdf147.34 kBAdobe PDFView/Open
09_chapter 4.pdf266.54 kBAdobe PDFView/Open
10_chapter 5.pdf992.65 kBAdobe PDFView/Open
11_chapter 6.pdf268.27 kBAdobe PDFView/Open
12_chapter 7.pdf366.22 kBAdobe PDFView/Open
13_chapter 8.pdf73.46 kBAdobe PDFView/Open
14_chapter 9.pdf288.19 kBAdobe PDFView/Open
15_conclusion.pdf92.43 kBAdobe PDFView/Open
16_references.pdf383.94 kBAdobe PDFView/Open
17_publications.pdf62.84 kBAdobe PDFView/Open

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