Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/153664
Title: Formulation and Characterization of Photosensitive Liposomes of Anticancer Drugs
Researcher: Sharma Neeraj
Guide(s): Vimal Kumar
Keywords: and#947;-Oryzanol
fluorouracil
Liposomes
Pharmacy
photosensitive
therapeutic
University: Nirma University
Completed Date: 27/09/2016
Abstract: Liposomes are tiny phospholipid bilayer vesicles intended to prepare for the safe and effective drug delivery. The prime purpose to formulate liposomes is to deliver potent and toxic drugs to improve their therapeutic efficiency. The flexibility of modification in liposomes make them a useful drug delivery system in various field like protein /drug delivery, controlled delivery, antiviral therapy, tumour therapy, gene delivery, vaccine delivery, cosmetics and dermatology and others. However, there are some stability issues and incomplete drug release at target site are attached with liposomes. In order to achieve maximum or appropriate therapeutic response drug in required quantity should be available to the target cells in the disease like cancer. newlineHence, considering the example of cancer, delivery of drug with liposomes to the site should be released in therapeutic concentration. For this purpose external stimuli can be used effectively to enhance the release of drug from liposomes. These approaches can use temperature, pH and light. The use of light to stimulate the release of encapsulated compounds from liposomes is attractive, because spatial and temporal delivery of the radiation can be possible to control. newlineIn the present study, to eradicate non therapeutic and toxic effects associated anticancer drugs like 5-fluorouracil (5-FU) and and#947;-Oryzanol (OZ) encapsulated reversed phase evaporation vesicles (REVs) carrying photoactive destabilization agent ketoprofen (KP) in the lipid bilayer were formulated. Effect of UV radiation activation of liposomal membrane incorporated KP on the destabilization of the liposome bilayer and the release of encapsulated drugs was investigated. newline5-FU loaded photosensitive liposomes and conventional liposomes were formulated and characterized. Lipid and cholesterol molar ratio was optimized on the basis of particle size and entrapment efficiency (% EE). Size of formulated photosensitive liposome was found 122 nm and with maximum % EE of 45.4 %. Further study included in vitro release
Pagination: 
URI: http://hdl.handle.net/10603/153664
Appears in Departments:Institute of Pharmacy

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