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Title: Hypobaric hypoxia mediated changes ill protein metabolism of skeletal muscle
Researcher: Chaudhary, Pooja
Guide(s): Ilavazhagan, G
Geetha S
Ali, Shakir
Keywords: Skeletal muscle
Hypobaric hypoxia
Oxidative stress
Upload Date: 24-Oct-2013
University: Jamia Hamdard University
Completed Date: 27/07/2012
Abstract: Exposure to high altitude hypoxia results in sustained muscle wasting. The present study is aimed at identifying the hind limb skeletal muscle more susceptible to hypobaric hypoxia and focused on understanding the molecular mechanisms that regulate skeletal muscle mass loss. The gastrocnemius muscle was found to be more susceptible to hypobaric hypoxia induced oxidative stress as reflected by increased levels of lipid peroxidation, free radical generation, protein carbonyl formation and nitric oxide levels. Gastrocnemius muscle also showed a significant depletion in the antioxidant status in addition to the increased oxidative stress. The evaluation of effects of acute and chronic hypobaric hypoxia on protein metabolism has shown that acute and chronic hypobaric hypoxia alters protein metabolism through different mechanisms. However, chronic hypobaric hypoxia leads to elevated skeletal muscle protein synthesis rate along with increased muscle proteolysis. It proves that synthesis rate is not a factor responsible for loss of skeletal muscle mass under chronic exposure. Chronic hypobaric hypoxia also resulted in loss of skeletal muscle integrity which was evident by decreased creatine phosphokinase activity in skeletal muscle homogenates. Histopathological studies provided significant evidence of skeletal muscle atrophy following different durations of exposure to chronic hypobaric hypoxia. The major protein affected during hypoxia is myosin heavy chain which constitutes the significant portion of myofibrillar proteins. NF-and#954;B has been found to be playing a significant role in muscle proteolysis. newlineThis study has also explored the dual role of curcumin as an anti-oxidant as well as inhibitor of NF-KB in preventing skeletal muscle mass loss following hypobaric hypoxia exposure.
Pagination: 208p.
Appears in Departments:Department of Biochemistry

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02_certificate.pdf776.11 kBAdobe PDFView/Open
03_acknowledgement.pdfAttached File11.21 kBAdobe PDFView/Open
04_contents.pdf140.57 kBAdobe PDFView/Open
05_chapter 1.pdf167.5 kBAdobe PDFView/Open
06_chapter 2.pdf1.01 MBAdobe PDFView/Open
07_chapter 3.pdf417.57 kBAdobe PDFView/Open
08_chapter 4.pdf605.3 kBAdobe PDFView/Open
09_chapter 5.pdf607.35 kBAdobe PDFView/Open
10_chapter 6.pdf937.05 kBAdobe PDFView/Open
11_chapter 7.pdf966.84 kBAdobe PDFView/Open
12_chapter 8.pdf1.07 MBAdobe PDFView/Open
13_chapter 9.pdf158.92 kBAdobe PDFView/Open
14_references.pdf375.35 kBAdobe PDFView/Open
15_publications.pdf1.58 MBAdobe PDFView/Open

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