Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/12216
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dc.coverage.spatialMedical Elementology and Toxicologyen_US
dc.date.accessioned2013-10-24T09:26:29Z-
dc.date.available2013-10-24T09:26:29Z-
dc.date.issued2013-10-24-
dc.identifier.urihttp://hdl.handle.net/10603/12216-
dc.description.abstractThe effort to develop effective therapies for acute ischemic stroke achieved several important successes during the past decade, but many disappointing failures also came through. Alternative therapeutic measures based on medicinal plants/herbs have also reported encouraging results. The plant products not only act synergistically with other compounds but also enhance the activity of other drugs/compounds or neutralize the toxicity of many chemicals. newlineThe plant products (Azadirachta seed extract, piperine, zingerone and capsaicin) used in this work, have been found to be effective against I/R injury at selected doses. Since each herbal compound/product has demonstrated its unique way of therapeutic intervention in rat MCAO model, the selected doses and the time-point at which the compounds were administered, are quite different, therefore it becomes difficult to make absolute comparison among them in order to predict more effective one. Prima facie, zingerone has been found to be more effective in terms of being good antioxidant and showing anti-apoptotic nature which mitigated I/R injury even when administered with delay of 3 h after MCAO. Capsaicin and piperine, although, has shown anti-ischemic and anti-inflammatory properties at the doses lower than that of zingerone, may not be regarded best medicines as they possess a narrow range of therapeutic index and higher doses of these may be detrimental to the brain cells. The only plant extract - Azadirachta seed extract used in this work seems to be most effective antioxidant but again it possesses lower ability of scavenging free radicals (DPPH).en_US
dc.format.extent192p.en_US
dc.languageEnglishen_US
dc.relation--en_US
dc.rightsuniversityen_US
dc.titleNeurobehavioral and neurochemical studies In Cerebral Ischemia and itsamelioration by herbal drugsen_US
dc.creator.researcherVaibhav Kumaren_US
dc.subject.keywordCerebral ischemiaen_US
dc.subject.keywordMedicinal plants-
dc.subject.keywordHerbal drugs-
dc.description.noteReferences p. 152-192, Appendix includeden_US
dc.contributor.guideIslam, Fakhrulen_US
dc.publisher.placeDelhien_US
dc.publisher.universityJamia Hamdard Universityen_US
dc.publisher.institutionDepartment of Medical Elementology and Toxicologyen_US
dc.date.registered2008en_US
dc.date.completed2013en_US
dc.date.awarded2013en_US
dc.format.dimensions--en_US
dc.format.accompanyingmaterialNoneen_US
dc.source.universityUniversityen_US
dc.type.degreePh.D.en_US
Appears in Departments:Department of Medical Elementology and Toxicology

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03_acknowledgement.pdfAttached File68.07 kBAdobe PDFView/Open
04_content.pdf23.65 kBAdobe PDFView/Open
05_chapter 1.pdf121.73 kBAdobe PDFView/Open
06_chapter 2.pdf4.8 MBAdobe PDFView/Open
07_chapter 3.pdf641.61 kBAdobe PDFView/Open
08_chapter 4.pdf2.26 MBAdobe PDFView/Open
09_chapter 5.pdf2.08 MBAdobe PDFView/Open
10_chapter 6.pdf2.7 MBAdobe PDFView/Open
11_chapter 7.pdf2.91 MBAdobe PDFView/Open
12_chapter 8.pdf168.17 kBAdobe PDFView/Open
13_bibliography.pdf1.21 MBAdobe PDFView/Open
14_appendix.pdf286.58 kBAdobe PDFView/Open
15_publications.pdf1.84 MBAdobe PDFView/Open


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