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Title: Neuropharmacological and molecular characterization of Okadaic acid induced neurodegeneration in rat
Researcher: Kamat, Pradip Kumar
Guide(s): Nath C
Ali, Shakir
Keywords: Okadaic acid
Sea foods
Oxidative stress
Herbal drugs
Upload Date: 24-Oct-2013
University: Jamia Hamdard University
Completed Date: 2012
Abstract: The present study is an investigation on the effect of intra cerebro ventricular (ICV) OKA on memory function in rat and associated biochemical, cellular, molecular and histological changes the brain. Due to increasing risk of chemical induced neurotoxicity and associated disorders in humans, a number of studies using pharmacological agents and natural extracts have been carried out to assess their neuroprotective potential in recent years. newlineOkadaic acid (OKA) is a selective inhibitor of the serine/threonine phosphatases 1 (PP1) and 2A (PP2A) and considered as a main culprit for memory impairment in the aged population using sea foods dinoflagellates (Helicondria Okadai) containing OKA. newline newlineThe investigation with OKA treated rat model has suggested that that OKA induces memory deficit and neurodegeneration in hippocampus and cortex along with Tau hyperphosphorylation. The major factors appear to be involved in OKA induced neurotoxicity are mitochondrial dysfunction, cholinergic dysfunction, neuroinflammation, oxidative stress and NMDA receptor. Moreover, efficacy of clinically used antidementic drugs against OKA induced changes concretes the validity of OKA induced memory impairment as an experimental model of dementia.
Pagination: 171p.
Appears in Departments:Department of Biochemistry

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02_acknowledgement.pdfAttached File10.13 kBAdobe PDFView/Open
03_content.pdf3.53 kBAdobe PDFView/Open
04_chapter 1.pdf90.62 kBAdobe PDFView/Open
05_chapter 2.pdf382.94 kBAdobe PDFView/Open
06_chapter 3.pdf368.14 kBAdobe PDFView/Open
07_chapter 4.pdf440.41 kBAdobe PDFView/Open
08_chapter 5.pdf322.35 kBAdobe PDFView/Open
09_chapter 6.pdf226.78 kBAdobe PDFView/Open
10_chapter 7.pdf267.68 kBAdobe PDFView/Open
11_chapter 8.pdf1.06 MBAdobe PDFView/Open
12_chapter 9.pdf104.72 kBAdobe PDFView/Open
13_chapter 10.pdf109.73 kBAdobe PDFView/Open
14_bibliography.pdf173.54 kBAdobe PDFView/Open
15_appendix.pdf77.06 kBAdobe PDFView/Open
16_publications.pdf137.15 kBAdobe PDFView/Open

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