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Title: Formulation and evaluation of Floating Drug Delivery Systems for some selected drugs
Researcher: Gangadharappa H V
Guide(s): Pramod Kumar T M
Keywords: Pharmaceutical Sciences
Losartan potassium
Floating Drug Delivery Systems
Verapamil hydrochloride
Floating tablet
Hollow microspheres
Upload Date: 24-May-2013
University: JSS University
Completed Date: December, 2012
Abstract: The purpose of this investigation was to develop a controlled release floating drug delivery system (tablets and hollow microspheres) of Losartan potassium, Verapamil hydrochloride and Rosiglitazone maleate. The aim of the first study was to develop and evaluate non-effervescent floating matrix tablets. Drugs having narrow absorption window and those which are absorbed mainly in stomach were developed as floating delivery system. Losartan potassium, a class I anti-hypertensive agent, is well absorbed in stomach and upper part of small intestine. Hence there is need to develop floating dosage form. Floating matrix tablets were prepared by direct compression method employing polypropylene foam powder (Accurel® MP 1000), Karaya gum and Chitosan. Tablets were characterized by FT-IR, DSC studies and evaluated for floating lag time, duration of buoyancy, friability, hardness, thickness, weight variation, swelling studies, drug content, in vitro drug release studies and in vivo studies. FT- IR and DSC studies showed that there is no interaction between the drug and excipients. The tablets showed zero floating lag time and remained buoyant for more than 12 h achieving the gastric retention properties. All evaluation parameters were within the Pharmacopoeial limits. The in vitro drug release was sustained up to 12 h and release rates were fitted into an empirical equation to compute the diffusion parameter which indicates a super case II- transport mechanism. X-ray photographs confirm presence of tablet in rabbit stomach for more than 12 h. The studies concluded that floating matrix tablets could be used as floating drug delivery systems in view of their floatation in stomach.
Pagination: 194p.
Appears in Departments:College of Pharmacy

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01_title.pdfAttached File219.45 kBAdobe PDFView/Open
02_certificates.pdf387.98 kBAdobe PDFView/Open
03_acknowledgements.pdf294.45 kBAdobe PDFView/Open
04_list of symbols.pdf159.68 kBAdobe PDFView/Open
05_abstract.pdf145.42 kBAdobe PDFView/Open
06_list of tables & figures.pdf220.16 kBAdobe PDFView/Open
07_progress of work.pdf180.14 kBAdobe PDFView/Open
08_contents.pdf99.72 kBAdobe PDFView/Open
09_chapter 1.pdf301.39 kBAdobe PDFView/Open
10_chapter 2-3.pdf1.42 MBAdobe PDFView/Open
11_chapter 4.pdf863.74 kBAdobe PDFView/Open
12_chapter 5.pdf1.04 MBAdobe PDFView/Open
13_chapter 6.pdf906.4 kBAdobe PDFView/Open
14_chapter 7.pdf1.02 MBAdobe PDFView/Open
15_chapter 8.pdf245.19 kBAdobe PDFView/Open
16_bibliography.pdf350.64 kBAdobe PDFView/Open
17_annexure & list of publications.pdf5.24 MBAdobe PDFView/Open

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