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Title: Transdermal delivery of newer atypical antipsychotics
Researcher: Aggarwal, Geeta
Guide(s): HariKumar, S L
Sanju Dhawan
Keywords: drug delivery
Upload Date: 16-May-2013
University: Punjab Technical University
Completed Date: 2011
Abstract: Risperidone and olanzapine, newer atypical antipsychotics are highly effective and safer in the treatment of psychosis. A low dose maintenance therapy of these atypical antipsychotics is needed for prolonged treatment of psychosis with lower oral side effects. To develop low dose maintenance therapy of these antipsychotics, which can minimize the risk of major side effects, help in overall cost saving and address to the problems of poor compliance in patients, eudragit containing transdermal films of risperidone and olanzapine were developed. For development of successful transdermal drug delivery system (TDDS), various permeation enhancers belonging to the group of surfactants (cationic surfactant, benzalkonium chloride (BC); anionic surfactant, sodium lauryl sulphate (SLS); non-ionic surfactant, span 20) and vegetable oils (olive oil, jojoba oil and groundnut oil) were also investigated in the present study to find out their effect on the rate of permeation of drug through TDDS. newlineThe whole research work was divided into various parts such as introduction, review of literature, preformulation studies, formulation and evaluation of TDDS of risperidone and olanzapine, in vivo studies, results and discussion and summary and conclusion. In preformulation studies, drugs were characterized by UV, IR, partition coefficient and solubility studies. FTIR studies were carried out to determine compatibility between drug and excipients. Transdermal patches of risperidone and olanzapine were prepared by solvent casting technique using Eudragit RL 100 (ERL 100) and Eudragit (ERS 100) with and without permeation enhancers (surfactants and vegetable oils in the concentration of 1%, 5% and 10% w/w of polymer weight). The prepared transdermal patches were evaluated for their physicochemical characterization viz., weight variation, thickness, drug content determination, moisture content and moisture uptake, flatness, folding endurance and tensile strength.
Pagination: ix, 190p.
Appears in Departments:Department of Pharmacy

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01_title.pdfAttached File47.62 kBAdobe PDFView/Open
02_declaration.pdf82.68 kBAdobe PDFView/Open
03_certificate.pdf35.68 kBAdobe PDFView/Open
04_abstract.pdf89.86 kBAdobe PDFView/Open
05_contents.pdf52.27 kBAdobe PDFView/Open
06_list of abbreviations.pdf104.24 kBAdobe PDFView/Open
07_list of figures.pdf98.29 kBAdobe PDFView/Open
08_list of publications.pdf45.46 kBAdobe PDFView/Open
09_list of tables.pdf99.34 kBAdobe PDFView/Open
10_chapter 1.pdf159.8 kBAdobe PDFView/Open
11_chapter 2.pdf91.21 kBAdobe PDFView/Open
12_chapter 3.pdf102.78 kBAdobe PDFView/Open
13_chapter 4.pdf645.78 kBAdobe PDFView/Open
14_chapter 5.pdf154.46 kBAdobe PDFView/Open
15_chapter 6.pdf1.44 MBAdobe PDFView/Open
16_chapter 7.pdf10.2 kBAdobe PDFView/Open
17_references.pdf189.9 kBAdobe PDFView/Open

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