Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/73020
Title: Determination of Uncojugated and total Ezetimibe in Human Plasma and its Application to Pharmacokinetic Studies
Researcher: Gaikwad Poonam Vithal
Guide(s): Bhoir Suvarna Indravadan
Keywords: Acetonitrile
Bioequivalence
Calibration Curve
Carryover Effect
EZM
Matrix Effect
Pharmacokinetics
Physicochemical
University: Narsee Monjee Institute of Management Studies
Completed Date: 
Abstract: The pharmacological response is generally related to the concentration of drug newlineat receptor site (Guidance for Industry: Bioavailability and Bioequivalence Studies for Orally Administered Drug Products-General Considerations, USFDA, 2003).The newlineavailability of a drug from the dosage form is a critical element of drug efficacy (Guidelines for Bioavailability and Bioequivalence Studies, CDSCO, 2005). newlineHowever, drug concentrations usually, cannot be readily measured directly at the site of action; therefore most bioavailability studies involve the determination of drug concentration in the biological matrix like blood, plasma, urine etc. This is based on the premise that the drug at the site of action is in equilibrium with drug in blood. It is therefore possible to obtain an indirect measure of drug response by monitoring drug level in biological matrix. The bio-analysis employed for the quantitative newlinedetermination of drug and metabolites in biological fluids plays a significant role in the evaluation of bioequivalence, pharmacokinetic and toxicological studies.
Pagination: 
URI: http://hdl.handle.net/10603/73020
Appears in Departments:Department of Chemical Sciences

Files in This Item:
File Description SizeFormat 
00. title page.pdfAttached File35.89 kBAdobe PDFView/Open
01. declaration by the student.pdf5.51 kBAdobe PDFView/Open
02. certificate.pdf5.39 kBAdobe PDFView/Open
03. acknowledgements.pdf8.2 kBAdobe PDFView/Open
04. list of contents.pdf30.23 kBAdobe PDFView/Open
05. list of abbreviations & symbols.pdf78.68 kBAdobe PDFView/Open
06. list of figures.pdf81.07 kBAdobe PDFView/Open
07. list of tables.pdf30.22 kBAdobe PDFView/Open
08. chapter 1.pdf240.08 kBAdobe PDFView/Open
09. chapter 2.pdf223.45 kBAdobe PDFView/Open
10. chapter 3.pdf1.13 MBAdobe PDFView/Open
11. chapter 4.pdf1.49 MBAdobe PDFView/Open
12. chapter 5.pdf1.87 MBAdobe PDFView/Open
13. chapter 6.pdf126.66 kBAdobe PDFView/Open
14. reference.pdf225.39 kBAdobe PDFView/Open


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