Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/7113
Title: Biological effects of feeding cuttle fish liver oil to rats
Researcher: Joseph, Sophia Margaret
Guide(s): Sherief, P M
Nair, J Rajasekharan
Keywords: immune function
cuttlefish liver oil
atherogenesis
eicosapentaenoic acid
docosahexaenoic acid
cardioprotective
Biochemistry
Upload Date: 27-Feb-2013
University: Mahatma Gandhi University
Completed Date: July, 2007
Abstract: The cuttlefish liver discarded during processing contains a high oil content (6- 40%) and is a rich source of and#969;-3 polyunsaturated fatty acids (and#969;-3 PUFAs) like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Feeding cuttlefish liver oil (CFLO) at 1% level to rats fed atherogenic diet (AD) for a period of 90 days, showed a lowering of gain in body weight and liver weight; lipid components in serum and tissues, LDL-cholesterol (LDL-C) and atherogenic ratio; increase in HDL-cholesterol (HDL-C), increased faecal excretion of bile acids and neutral sterols; decreased lipogenic enzyme activities, increased antioxidant enzyme activities and antioxidant levels, but, decreased levels of lipid peroxidation products in tissues. The antiatherogenic action of CFLO observed is through decreased lipogenesis, increased cholesterol transport to liver, enhanced excretion of neutral sterols and bile acids and above all a stimulated antioxidant defense system and this might be due to its high content of and#969;-3 PUFAs which in the presence of antioxidants (vitamins E and C and green tea flavonoids) offer greater effect. The cardioprotective action, immune function, inflammatory response and platelet aggregation was also studied by feeding 1 % CFLO for a period of 45 days. The study showed lowering of the levels of diagnostic marker enzymes, enhanced proliferation of spleen and bone marrow cells, increase in the number of plaque forming cells in the spleen and antibody titre in the circulation; inhibition of carrageenan induced acute paw oedema, formalin induced chronic paw oedema and adenosine diphosphate (ADP) induced platelet aggregation. The and#969;-3 PUFAs especially the EPA present in the CFLO may be responsible for the observed beneficial effects.
Pagination: 150p.
URI: http://hdl.handle.net/10603/7113
Appears in Departments:School of Bio Sciences

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01_title.pdfAttached File25.36 kBAdobe PDFView/Open
02_dedication.pdf24.38 kBAdobe PDFView/Open
03_declaration.pdf21.34 kBAdobe PDFView/Open
04_certificate.pdf22.41 kBAdobe PDFView/Open
05_acknowledgements.pdf24.03 kBAdobe PDFView/Open
06_abbreviations.pdf33.62 kBAdobe PDFView/Open
07_abstract.pdf29.44 kBAdobe PDFView/Open
08_contents.pdf22.52 kBAdobe PDFView/Open
09_list of tables.pdf32.48 kBAdobe PDFView/Open
10_list of figures.pdf30.7 kBAdobe PDFView/Open
11_chapter 1.pdf381 kBAdobe PDFView/Open
12_chapter 2.pdf144.5 kBAdobe PDFView/Open
13_chapter 3.pdf611.34 kBAdobe PDFView/Open
14_chapter 4.pdf90.47 kBAdobe PDFView/Open
15_chapter 5.pdf99.84 kBAdobe PDFView/Open
16_chapter 6.pdf71.65 kBAdobe PDFView/Open
17_summary.pdf49.04 kBAdobe PDFView/Open
18_references.pdf340.88 kBAdobe PDFView/Open


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