Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/7082
Title: Design of toxicant imprinted polymers with high specificity and selectivity
Researcher: Philip, C Mercy
Guide(s): Mathew , Beena
Keywords: selectivity
molecular imprinting
monomer template ratio
crosslinking
nicotine
theophylline
caffeine
Scatchard plot
specificity
Upload Date: 26-Feb-2013
University: Mahatma Gandhi University
Completed Date: May 2007
Abstract: Molecularly imprinted polymers (MIPs) of a few substances that have toxicity at higher doses (nicotine, theophylline and caffeine) were prepared by bulk polymerization. To compare and analyse the binding efficiency of the MIPs, non-imprinted polymers (NIPs) were also prepared. Various spectroscopic methods such as FT-IR and 1H NMR were employed for analyzing pre-polymerisation solutions and for polymer characterization. Scanning electron microscopy gave the surface morphological differences between imprinted and non-imprinted polymers. Emphasis was given on the designing of imprinted polymers with maximum specificity and selectivity, by altering the nature and degree of crosslinking in the imprinted system as well as by observing the various parameters related to rebinding. The influence of different synthetic conditions such as nature of crosslinking agents, monomer-template ratio, extent of crosslinking and time of equilibrium on recognition properties of the polymers was investigated using UV-spectroscopic method. Scatchard analysis was done to evaluate the binding parameters of the imprinted polymers. The selectivity of MIPs was evaluated by rebinding the structurally similar compounds. The results indicated that the imprinted polymers exhibited an excellent selectivity towards the imprinted molecules.
Pagination: 157p.
URI: http://hdl.handle.net/10603/7082
Appears in Departments:School Of Chemical Science

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01_title.pdfAttached File35.44 kBAdobe PDFView/Open
02_dedication.pdf23.76 kBAdobe PDFView/Open
03_declaration.pdf27.88 kBAdobe PDFView/Open
04_certificate.pdf29.05 kBAdobe PDFView/Open
05_acknowledgements.pdf38.71 kBAdobe PDFView/Open
06_abstract.pdf37.5 kBAdobe PDFView/Open
07_list of abbreviations.pdf45.65 kBAdobe PDFView/Open
08_contents.pdf73.21 kBAdobe PDFView/Open
09_list of figures.pdf58.66 kBAdobe PDFView/Open
10_list of tables.pdf51.77 kBAdobe PDFView/Open
11_list of schemes.pdf34.79 kBAdobe PDFView/Open
12_chapter 1.pdf100.62 kBAdobe PDFView/Open
13_chapter 2.pdf497.33 kBAdobe PDFView/Open
14_chapter 3.pdf202.03 kBAdobe PDFView/Open
15_chapter 4.pdf3.52 MBAdobe PDFView/Open
16_chapter 5.pdf39.23 kBAdobe PDFView/Open


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