Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/70422
Title: Biochemical studies during progression of chemically induced hepatic fibrosis and its attenuation by resveratrol
Researcher: AREEBA AHMAD
Guide(s): Dr. Riaz Ahmad
Keywords: hepatic fibrosis
University: Aligarh Muslim University
Completed Date: n.d.
Abstract: Liver, the largest and the most vital organ, is of approximately 1.5 kg in an adult human. The organ is localized in the abdominal cavity between the digestive tract and the spleen. Liver is comprised of two principal lobes; right lobe and left lobe, separated by the falciform ligament. The basic functional unit of the liver is the lobule, which is hexagonal in shape with a central terminal and the portal triads at the corners of the hexagon. The hepatocytes, arranged symmetrically in cords around the central vein, are separated by liver sinusoids in which blood flows from portal triads towards the central vein. The liver has a double blood supply; most of blood influx is through the portal vein which brings nutrient-loaded blood from the digestive tract while the hepatic artery provides oxygen-rich blood. Anatomically the liver is comprised of elementary functional units (i.e. lobules), which are comprised of three major liver cell types: (1), the parenchymal cells or hepatocytes; (ii), the sinusoidal endothelial cells lining the sinusoids and a resident macrophage population, known as Kupffer cells and (iii), hepatic stellate cells, hypothesized of being mesenchymal in origin are positioned in the peri-sinusoidal space of Disse by means of star-like dendritic cytoplasmic processes. The liver is involved in a variety of functions ranging from synthesizing of substances to their transport to different parts of the body. Any injury or infection to the liver may hamper its proper functioning and that could lead to a liver disease. One such disease is hepatic fibrosis (or liver fibrosis) that is characterized by a series of clinical complications subsequent to abnormal proliferation and amassing of tough fibrous collagen (scar) tissue. This erroneous growth and defiance of collagen fibers happen to be fatal due to ultimate failure of the hepatic functioning. This process involves interplay of diverse cell types in the liver and exemplifies the imbalance between extracellular matrix (ECM) synthesis or its deposition
Pagination: 191
URI: http://hdl.handle.net/10603/70422
Appears in Departments:Department of Zoology

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chapter1.pdf315.12 kBAdobe PDFView/Open
chapter2.pdf57.93 kBAdobe PDFView/Open
chapter3.pdf128.76 kBAdobe PDFView/Open
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chapter5.pdf273.11 kBAdobe PDFView/Open
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summary.pdf102.93 kBAdobe PDFView/Open
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