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Title: Safety evaluation of certain NSAIDs in birds
Researcher: Mohan K
Guide(s): Jayakumar K
Keywords: Veterinary Sciences
Veterinary Pharmacology and Toxicology
Upload Date: 18-Feb-2013
University: Karnataka Veterinary, Animal and Fisheries Sciences University
Completed Date: 26/05/2010
Abstract: The present study was carried out to evaluate the safety of certain NSAIDs viz. aspirin, paracetamol, ketoprofen, nimesulide, meloxicam and celecoxib in broiler chickens. Forty-eight, healthy, broiler chickens were randomly divided into 8 groups consisting of 6 birds in each group. Group I served as control and received 1.5 ml of distilled water P.O., where as group II, III, IV, V, VI, VII and VIII received 2.5 mg of newlinediclofenac, 10 mg of aspirin, 10 mg of paracetamol, 2 mg of nimesulide, 4 mg of newlineketoprofen, 0.5 mg of meloxicam and 3.5 mg of celecoxib, respectively, P.O., for five newlinedays. Manifestation of clinical signs of toxicity such as anorexia, disinclination to move within the cage, lethargy, depression, recumbency, shrunken eyes and blood in the faecal droppings or mucous mixed diarrhea observed for some groups were considered as newlineNSAID toxicity. Significant increase in serum biochemical parameters such as AST, ALT, ALP, BUN, creatinine and uric acid and significant decrease in serum albumin and total protein concentrations observed in some of the treatment groups such as diclofenac, aspirin, paracetamol and nimesulide during and later part of the study period are indicative of toxic effects of these drugs on intestines, liver and kidneys. However, no adverse reactions or toxic clinical signs, no major alterations in serum biochemical parameters and no gross or histopathological lesions were observed in any of the vital organs examined in treatment groups involving ketoprofen, meloxicam and celecoxib. newlineThus, it was concluded that, NSAIDs, ketoprofen, meloxicam and celecoxib at the dose of 4, 0.5 and 3.5 mg/kg, respectively administered orally for five days considered being safe for use in birds when compared to that of other NSAIDs, viz., diclofenac, aspirin, paracetamol and nimesulide for the dose and duration of the study undertaken.
Pagination: 170p.
Appears in Departments:Department of Pharmacology and Toxicology

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01_title.pdfAttached File10.97 kBAdobe PDFView/Open
02_certificate & acknowledgement.pdf21.63 kBAdobe PDFView/Open
03_contents.pdf9.55 kBAdobe PDFView/Open
04_list of figures tables plates & abbreviations.pdf40.47 kBAdobe PDFView/Open
05_chapter 1.pdf19.83 kBAdobe PDFView/Open
06_chapter 2.pdf137 kBAdobe PDFView/Open
07_chapter 3.pdf57.87 kBAdobe PDFView/Open
08_chapter 4.pdf2.4 MBAdobe PDFView/Open
09_chapter 5.pdf82.01 kBAdobe PDFView/Open
10_summary.pdf20.52 kBAdobe PDFView/Open
11_bibliography.pdf90.17 kBAdobe PDFView/Open
12_abstract.pdf2.76 MBAdobe PDFView/Open

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