Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/66978
Title: Studies on the preparations of stabilized sulfenyl bromides their electrophilic reactions and their antibacterial activity
Researcher: Barman, Pranjit
Guide(s): Bhattacharjee, S K
Keywords: Antibacterial
Bromides
Calorimetry
Carbon-Sulfur
Electrophilic
Stabilized
Sulfenyl
University: Gauhati University
Completed Date: 31/12/2002
Abstract: The contents of the thesis is divided into six chapters. In this is abstract a summary of each chapter is included. Chapter (I) In this chapter an introduction of the synthesis of carbon-sulfur bond in bivalent organic sulfur compounds is included. Difficulties in preparing such bond with electron rich substrates have been discussed. For such substrates electrophilic bivalent organic sulfur reagents are neccessary. Unfortunately, most of these are unstable. In this chapter the preparations of some stabilized sulfenyl compounds (I), and (II) have been discussed. These newly synthesized sulfenyl compounds act as electrophilic bivalent organo sulfur reagents. Findings of the studies of the physical properties of (I), by uv and visible spectroscopy, differential scanning calorimetry and thermogravimetry and X-ray diffraction method have been discussed in this chapter. These studies throw some light on the origin of the stabilizing forces on the sulfenyl group of (I). From these observations an attempt has been made to predict the effect of the substituents (Y,Z) on the reactivities of (I) which is put to test in reactions of these compounds with different substrates and the results of these studies have been reported in the subsequent chapters. Chapter (II) A. In this chapter reactions of azobenzene-2-sulfenylbromides (I, X=Br) with nucleophilic solvents and bases have been discussed. Sulfenic acids RSOH are inherently unstable due to their ability to function both as an electrophile and a nucleophile to undergo bimolecular substitution reaction to give corresponding thiolsulfinates (III) For this reason only very few sulfenic acids could be synthesized in last 70 years. The inherent instability of the sulfenic acids RSOH can be slowed down if the bulk of R is large or if a proton accepting group is present in the group R which can intramolecularly accept a proton from the S-OH group. Azobenzene-2-sulfenylbromides (44) fulfil both of these conditions. They have a bulky R-group in the form of 2-arylazophenyl group and
Pagination: 
URI: http://hdl.handle.net/10603/66978
Appears in Departments:Department of Chemistry

Files in This Item:
File Description SizeFormat 
01_title page.pdfAttached File21.17 kBAdobe PDFView/Open
02_certificate.pdf26.04 kBAdobe PDFView/Open
03_acknowledgement.pdf31.05 kBAdobe PDFView/Open
04_content.pdf119.27 kBAdobe PDFView/Open
05_abstract.pdf258.08 kBAdobe PDFView/Open
06_chapter 1.pdf251.4 kBAdobe PDFView/Open
07_chapter 2.pdf1.07 MBAdobe PDFView/Open
08_chapter 3.pdf545.72 kBAdobe PDFView/Open
09_chapter 4.pdf301.33 kBAdobe PDFView/Open
10_chapter 5.pdf709.35 kBAdobe PDFView/Open
11_chapter 6.pdf481.55 kBAdobe PDFView/Open
12_chapter 7.pdf212.77 kBAdobe PDFView/Open
13_chapter 8.pdf361 kBAdobe PDFView/Open
14_bibliography.pdf296.2 kBAdobe PDFView/Open
15_appendix.pdf203.64 kBAdobe PDFView/Open
16_list of publication.pdf1.67 MBAdobe PDFView/Open


Items in Shodhganga are protected by copyright, with all rights reserved, unless otherwise indicated.