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Title: Preliminary phytochemical study and anti arthritic potential of curcuma zedoaria rosc root
Researcher: Madan Lal Kaushik
Guide(s): Jalalpure, Sunil S
Keywords: Curcuma zedoaria Rosc
Freund s Complete Adjuvant
Griess assay
Vascular permeability
Stability study
Upload Date: 27-Dec-2012
University: KLE University
Completed Date: February 2012
Abstract: Objective: The aim of the present study was to investigate the anti-arthritic and acute anti-inflammatory effects of petroleum ether, chloroform, methanol, ethanol and aqueous extract of Curcuma zedoaria root and its formulation from potent extracts on Freund s Complete Adjuvant (FCA) induced arthritis, carrageenan and histamine induced paw edema in rats. The separation and characterization of phytoconstituents from potent extract was carried out along with the accelerated stability study of formulations. Methods: Roots of C. zedoaria were collected, shade dried and the dried powdered material was subjected to successive extraction with increasing polarity of solvent such as petroleum ether (40-60), chloroform, methanol and ethanol. Aqueous extract was obtained by subjecting the dried ethanol marc by cold maceration. The present study was undertaken as per FDA- USA guidelines for industrial preclinical anti-arthritic research. The anti-arthritic activity was evaluated by using Freund s Complete Adjuvant induced arthritic rat model and the process of recovery was studied by considering clinical, behavioral, histopathological and radiographic changes. The change in body weight, and hematological studies such as WBC, RBC, ESR and hemoglobin content were considered as parameter for health profile. The effect on vascular permeability and synthesis of nitric oxide were used to evaluate the possible molecular mechanism of action. The carrageenan and histamine induced paw edema were used to evaluate the acute anti-inflammatory effects. Results: No toxic effects were observed at 2000 mg/kg body weight of each extract of C. zedoaria. The statistical data indicates that, petroleum ether, chloroform and ethanol extracts at 200 and 400 mg/kg showed potent antiarthritic and acute anti-inflammatory activity. These extracts reduced FCA-induced paw edema in arthritic rats and significant (plt0.001) recovery in hematological (ESR and HB), and behavioral changes.
Pagination: 184p.
Appears in Departments:Faculty of Pharmacy

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01_title.pdfAttached File270.88 kBAdobe PDFView/Open
02_certificates.pdf342.74 kBAdobe PDFView/Open
03_acknowledgements.pdf253.7 kBAdobe PDFView/Open
04_abstract.pdf42.85 kBAdobe PDFView/Open
05_contents.pdf88.91 kBAdobe PDFView/Open
06_list of tables.pdf64.04 kBAdobe PDFView/Open
07_list of figures.pdf48.52 kBAdobe PDFView/Open
08_abbreviations.pdf158.9 kBAdobe PDFView/Open
09_synopsis.pdf796.26 kBAdobe PDFView/Open
10_chapter 1.pdf153.13 kBAdobe PDFView/Open
11_chapter 2.pdf180.07 kBAdobe PDFView/Open
12_chapter 3.pdf662.26 kBAdobe PDFView/Open
13_chapter 4.pdf429.93 kBAdobe PDFView/Open
14_chapter 5.pdf1.97 MBAdobe PDFView/Open
15_chapter 6.pdf276.48 kBAdobe PDFView/Open
16_chapter 7.pdf138.91 kBAdobe PDFView/Open
17_summary.pdf279.99 kBAdobe PDFView/Open
18_bibliography.pdf185.23 kBAdobe PDFView/Open
19_appendices.pdf8 MBAdobe PDFView/Open

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