ANTIMICROBIAL ACTIVITY OF CATIONIC SYNTHETIC PEPTIDES

Abstract

Infections have been the major cause of disease throughout the history of human population The emergence of pathogenic bacterial resistance to available conventional antibiotics is a major threat in treatment of infectious diseases E faecalis is a gram positive cocci and a facultative anaerobe is the predominant microbe in 4 to 40 percentage of endodontic infection responsible for dental plaque and biofilm formation Besides E faecalis the other predominant microbe C albicans has been repeatedly identified as the species most commonly recovered from root canals undergoing treatment in cases of failed endodontic therapy and canals with persistent infections Hence the aim of the study is to determine the antimicrobial efficacy of the cationic synthetic peptides results suggest that the CAMPs VSL2 and VS2 showed potent activity against E faecalis and C albicans majorly involved in root canal infections These CAMPs were also found to be biocompatible and not genotoxic and hence all these properties prove that these CAMPs can be developed as worthy candidates to treat various infections newline newline newline