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Title: Study of lead exposure and outcomes amongst children in Chennai India
Researcher: Kavitha P L
Guide(s): Balakrishnan, Kalpana
Keywords: Health Sciences
Environmental health problem
Lead exposure poses
Upload Date: 5-Sep-2012
University: Sri Ramachandra Medical College and Research Institute
Completed Date: September, 2007
Abstract: Lead exposure poses a major environmental health problem in India, where direct studies on a large-scale have not yet been performed to investigate its impact on the intelligence quotient, neurobehavioral development, status of anemia and growth of children. This cross-sectional epidemiological study was done to resolve the above purpose and to determine the health effects of lead exposure on children aged 3 ? 7 years attending specific public schools. The schools were chosen to represent different traffic and industrial density areas in Chennai. The study sample constituted 814 children to whom the standard IQ and neurobehavioral tests were administered. Behavioral rating questionnaires were administered to the respective teachers. Socio-demographic and economic data were collected from each child?s primary caregiver. Fresh whole blood samples collected from the children was tested for lead, complete blood count and serum ferritin concentrations. The resultant data was analyzed using SPSS version 13.0 and R version 2.5.1. The mean blood lead was 11.5 µg/dL and 54.5% of the study population had blood lead levels above 10 µg/dL. Low standard of living, residence in high industry/high traffic zone and use of brass or bronze vessels correlated significantly with high blood lead levels. After adjusting for confounding factors, every 10 µg/dL increase of blood lead level resulted in a decrease of 2.83 IQ points, 5.42 points in visual-motor abilities scale and an increase of 2.2 points on the inattentiveness scale and 6.97 points on the global executive functions scale. Non-linear association was also observed between blood lead levels and IQ and neurobehavioral development. Steepest declines in IQ and neurobehavioral development were seen at blood lead levels below 5 µg/dL. A significant increase in mean blood lead concentration was observed with the development of iron deficiency anemia from one phase to another. However, anemia was more prominent in children with blood lead levels above 10 µg/dL.
Pagination: xxvi, 220p.
Appears in Departments:College of Allied Health & Sciences

Files in This Item:
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01_title.pdfAttached File23.34 kBAdobe PDFView/Open
02_certificate & declaration.pdf54.82 kBAdobe PDFView/Open
03_acknowledgements.pdf46.69 kBAdobe PDFView/Open
04_abstract.pdf45.67 kBAdobe PDFView/Open
05_table of contents.pdf50.39 kBAdobe PDFView/Open
06_list of tables & figures.pdf60 kBAdobe PDFView/Open
07_list of symbols & abbreviations.pdf66.94 kBAdobe PDFView/Open
08_chapter 1.pdf260.28 kBAdobe PDFView/Open
09_chapter 2.pdf70.33 kBAdobe PDFView/Open
10_chapter 3.pdf1.27 MBAdobe PDFView/Open
11_chapter 4.pdf753.12 kBAdobe PDFView/Open
12_chapter 5.pdf36.43 kBAdobe PDFView/Open
13_references.pdf111.34 kBAdobe PDFView/Open
14_annexure.pdf215.78 kBAdobe PDFView/Open

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