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Title: Formulation development and biopharmaceutical assessment of nanoparticle technology based oral drug delivery system
Researcher: Nekkanti, Vijay Kumar
Guide(s): Venkateswarlu, V
Pillai, Raviraj
Keywords: Drug Nanoparticles
Piston gap Technologies
Differential Scanning Calorimetry (DSC)
X-ray Powder Diffraction (XRPD)
oral drug delivery system
Upload Date: 3-Sep-2012
University: Jawaharlal Nehru Technological University
Completed Date: December, 2010
Abstract: Poorly water-soluble drugs such as Candesartan cilexetil and Camptothecin analog offer challenges in developing a drug product with adequate bioavailability. The bioavailability of these drugs is dissolution limited following oral administration. The objective of this study was to develop a tablet dosage form for these drugs incorporating drug nanoparticles to increase their saturation solubility and dissolution velocity for enhancing oral bioavailability while reducing variability in systemic exposure. Drug nanoparticles were prepared using a wet bead milling technique and the milled nanosuspensions were converted into solid intermediate using either a spray drying or spray granulation process. The nanosuspensions were characterized for particle size before and after drying process. The drug nanoparticles were evaluated for solid-state transitions before and after milling using differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). The surface morphology of drug nanoparticles was evaluated by Scanning Electron Microscopy (SEM). The dried granules were blended with extra granular excipients for tableting. The saturation solubility and dissolution characteristics of the nanoparticle tablet formulations were investigated and compared with micronized and ?as-is? drug formulations to ascertain the impact of particle size on drug dissolution. The systemic exposures of nanoparticle formulations were evaluated in male Wistar rats for assessing increase in the rate and extent of drug absorption. The results demonstrated that there were no solid-state transitions upon milling; the scanning electron micrographs illustrate, the recrystallization of water soluble carrier creates a highly hydrophilic environment around the drug preventing particle interaction and aggregation, there was a significant enhancement in dissolution rate for tablet dosage form incorporating drug nanoparticles as compared to the un-milled and micronized drug.
Pagination: 199p.
Appears in Departments:Faculty of Pharmaceutical Sciences

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01_title.pdfAttached File55.66 kBAdobe PDFView/Open
02_declaration.pdf40.79 kBAdobe PDFView/Open
03_certificates.pdf93.51 kBAdobe PDFView/Open
04_acknowledgements.pdf33.74 kBAdobe PDFView/Open
05_abstract.pdf62.65 kBAdobe PDFView/Open
06_table of contents.pdf273.87 kBAdobe PDFView/Open
07_list of tables.pdf102.53 kBAdobe PDFView/Open
08_list of figures.pdf98.42 kBAdobe PDFView/Open
09_list of photographs.pdf11.73 kBAdobe PDFView/Open
10_list of notations.pdf14.52 kBAdobe PDFView/Open
11_chapter 1.pdf39.57 kBAdobe PDFView/Open
12_chapter 2.pdf191.71 kBAdobe PDFView/Open
13_chapter 3.pdf3.15 MBAdobe PDFView/Open
14_chapter 4.pdf72.24 kBAdobe PDFView/Open
15_chapter 5.pdf145.27 kBAdobe PDFView/Open
16_chapter 6.pdf771.81 kBAdobe PDFView/Open

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