Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/37468
Title: INVESTIGATION OF FOLATE PATHWAY GENE POLYMORPHISMS IN NON SYNDROMIC CLEFT LIP WITH OR WITHOUT CLEFT PALATE IN SOUTH INDIAN POPULATION
Researcher: JYOTSNA MURTHY. Dr
Guide(s): BHASKAR L.V.K.S Dr
Keywords: FOLATE PATHWAY
NON SYNDROMIC CLEFT LIP
POLYMORPHISMS
SOUTH INDIAN POPULATION
Upload Date: 17-Mar-2015
University: Sri Ramachandra University
Completed Date: 07/02/2015
Abstract: This thesis describes demographic and associated anomalies in cleft children attending outpatient department of hospital for surgery in South India Two thousand and five children were examined for associated anomalies and syndromes The CLP and CL were more common in males and CPO was more common in females The results of the present study provide demographic details of the cleft children in the South India In addition to this the association of important polymorphisms from genes encoding folate homocysteine and methionine metabolism detoxification with nonsyndromic cleft lip and palate in the South Indian population was studied The subjects included 142 cases with nonsyndromic oral clefts and 141 control individuals without clefts or family history of clefting The genotyping was done using published PCRRFLP methods The associations between genotypes alleles and haplotypes of the polymorphic sites and nonsyndromic clefts were then analyzed using a casecontrol study The strength of the association between gene variants and nonsyndromic cleft lip and palate was estimated using the logistic regression using the chisquare test The genotype frequencies were consistent with HardyWeinberg equilibrium in the control group for all SNPs except MTRR A66G polymorphism newlineThis thesis describes demographic and associated anomalies in cleft children attending outpatient department of hospital for surgery in South India Two thousand and five children were examined for associated anomalies and syndromes The CLP and CL were more common in males and CPO was more common in females The results of the present study provide demographic details of the cleft children in the South India In addition to this the association of important polymorphisms from genes encoding folate homocysteine and methionine metabolism detoxification with nonsyndromic cleft lip and palate in the South Indian population was studied The subjects included 142 cases with nonsyndromic oral clefts and 141 control individuals without clefts or family history of cleftin
Pagination: 1-200
URI: http://hdl.handle.net/10603/37468
Appears in Departments:Medical College

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10. abstract.pdfAttached File53.47 kBAdobe PDFView/Open
16.references.pdf249.56 kBAdobe PDFView/Open
17.appendix1.pdf290.13 kBAdobe PDFView/Open
18.appendix2.pdf245.28 kBAdobe PDFView/Open
19.appendix3.pdf130.74 kBAdobe PDFView/Open
1. front pages1.pdf57.93 kBAdobe PDFView/Open
20.appendix4.pdf427.58 kBAdobe PDFView/Open
21.appendix5.pdf57.23 kBAdobe PDFView/Open
2. declaration.pdf31.27 kBAdobe PDFView/Open
3. certificate guide.pdf30.16 kBAdobe PDFView/Open
4. certificate co-guide.pdf35.28 kBAdobe PDFView/Open
5. acknowledgement.pdf9.99 kBAdobe PDFView/Open
6. table of content.pdf86.88 kBAdobe PDFView/Open
7. list of tables.pdf54.59 kBAdobe PDFView/Open
8. list of figures.pdf55.11 kBAdobe PDFView/Open
9. abbreviations.pdf60.35 kBAdobe PDFView/Open
chapter iii.pdf1.41 MBAdobe PDFView/Open
chapter ii.pdf832.62 kBAdobe PDFView/Open
chapter i.pdf580.19 kBAdobe PDFView/Open
chapter iv.pdf114.38 kBAdobe PDFView/Open
chapter v.pdf9.75 kBAdobe PDFView/Open


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