Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/3688
Title: Fabrication of electrochemical sensors for pharmaceutical analysis
Researcher: John, Sareena
Guide(s): Girish Kumar, K
Keywords: Electrochemical Sensors
Pharmaceuticals
Potentiometric Sensors
Mebendazole
Sildenafil citrate
Dextromethorphan
Upload Date: 24-Apr-2012
University: Cochin University of Science and Technology
Completed Date: 06/12/2007
Abstract: Potentiometric chemical sensors, an important class of electro-chemical sensors are widely used in pharmaceutical analysis because of its inherent advantages. The present study was aimed at fabrication of potentiometric sensors for the drugs mebendazole, pefloxacin, ambroxol, sildenafil citrate, dextro methorphan and tetracycline. A total of 18 sensors have been developed for the determination of theses drugs. The major step in the fabrication of the sensor was the preparation of the ion association. Two types of sensors viz: PVC membrane sensor and carbon paste electode (CPE) were fabricated. The response characteristics of the different sensors fabricated were studied. Various response parameters studied include response time, selectivity and the effect of pH. The developed sensors were also employed for the determination of the drugs in pharmaceutical formulations and also for the recovery of the drug from urine samples. The selectivity studies reveal that the developed sensors are highly selective to the drug even in prescence of foreign ions.
Pagination: 218p.
URI: http://hdl.handle.net/10603/3688
Appears in Departments:Department of Applied Chemistry

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01_title.pdfAttached File20.34 kBAdobe PDFView/Open
02_certificate.pdf21.39 kBAdobe PDFView/Open
03_declaration.pdf16.92 kBAdobe PDFView/Open
04_acknowledgements.pdf36.04 kBAdobe PDFView/Open
05_preface.pdf48.69 kBAdobe PDFView/Open
06_table of contents.pdf74.08 kBAdobe PDFView/Open
07_chapter 1.pdf522.27 kBAdobe PDFView/Open
08_chapter 2.pdf245.94 kBAdobe PDFView/Open
09_chapter 3.pdf296.43 kBAdobe PDFView/Open
10_chapter 4.pdf397.45 kBAdobe PDFView/Open
11_chapter 5.pdf253.25 kBAdobe PDFView/Open
12_chapter 6.pdf333.47 kBAdobe PDFView/Open
13_chapter 7.pdf385.88 kBAdobe PDFView/Open
14_chapter 8.pdf277.6 kBAdobe PDFView/Open
15_chapter 9.pdf49.67 kBAdobe PDFView/Open
16_references.pdf393.3 kBAdobe PDFView/Open
17_list of publications.pdf42.27 kBAdobe PDFView/Open


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