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Title: Studies directed towards the synthesis of dithiocarbamates and its application in organic synthesis
Researcher: Katari, Naresh Kumar
Guide(s): Mukkanti, K
Keywords: Dithiocarbamates
Organic synthesis
Upload Date: 19-Apr-2012
University: Jawaharlal Nehru Technological University
Completed Date: April, 2011
Abstract: Investigation embodied in this thesis entitled “Studies directed towards the synthesis of dithiocarbamates and its application in organic synthesis” divided into four chapters, which are as follows: Chapter I: Introduction, synthesis of dithiocarbamates and its application Introduction chapter deals with the important features of dithiocarbamates and its synthesis. A dithiocarbamate is a functional group in organic chemistry. It is the analogue of carbamate in which both oxygen atoms are replaced by sulfur atoms (figure 1). Organic dithiocarbamates are valuable synthetic intermediates. They also exhibit valuable biological effects, including anticancer, antibacterial and antifungal activity. Dithiocarbamic acid ester represents a new kind of compound with a novel structure, significant anticancer activity and very low toxicity. Figure 1: General formula of the dithiocarbamate N S R3 S R1 R2 Dithiocarbamates have received considerable attention due to their numerous biological activities and their pivotal role in agriculture and as linkers in solid phase organic synthesis. They are also used in the rubber industry as vulcanization accelerators and in controlled radical polymerization techniques. Because they have a ix strong metal binding capacity, they can also act as inhibitors of enzymes and have a profound effect on biological systems. Dithiocarbamates are also widely used in medicinal chemistry and have found application in the treatment of cancer (figure 2). Furthermore; dithiocarbamates are versatile classes of ligands with the ability to stabilize transition metals in a wide range of oxidation states. Figure 2: Structures of dithiocarbamates with anti cancer activity Recently, Brassinin (figure 3), a dithiocarbamate isolated from cabbage, was reported to have anticancer activity, and its structural modification led to the design and synthesis of a potential cancer chemopreventive agent (4-methanesulfinyl-butyl)-dithiocarbamic acid methyl ester (Sulforamate).
Pagination: lxvi, 485p.
Appears in Departments:Department of Chemistry

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File Description SizeFormat 
01_title.pdfAttached File140.6 kBAdobe PDFView/Open
02_dedication.pdf120.52 kBAdobe PDFView/Open
03_certificate.pdf155.33 kBAdobe PDFView/Open
04_declaration.pdf144.98 kBAdobe PDFView/Open
05_acknowledgements.pdf114.09 kBAdobe PDFView/Open
06_abstract of the thesis.pdf234.04 kBAdobe PDFView/Open
07_table of contents.pdf156.24 kBAdobe PDFView/Open
08_list of tables & figures.pdf400.91 kBAdobe PDFView/Open
09_list of compounds.pdf232.13 kBAdobe PDFView/Open
10_abbreviations.pdf170.65 kBAdobe PDFView/Open
11_general methodology.pdf139.23 kBAdobe PDFView/Open
12_chapter 1.pdf4.65 MBAdobe PDFView/Open
13_chapter 2.pdf7.39 MBAdobe PDFView/Open
14_chapter 3.pdf10.38 MBAdobe PDFView/Open
15_chapter 4.pdf9.33 MBAdobe PDFView/Open
16_list of publications.pdf183.96 kBAdobe PDFView/Open
17_publication.pdf125.05 kBAdobe PDFView/Open

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