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Title: Development of chronotherapeutic formulation for anti-asthmatic drugs
Researcher: Narendra, C
Guide(s): Srinath, M S
Keywords: Pharmaceutical Sciences
Anti-asthmatic drugs
Chronotherapeutic Drug Delivery System
Drug Delivery System
Upload Date: 19-Apr-2012
University: Jawaharlal Nehru Technological University
Completed Date: November, 2010
Abstract: The main objective of this work was to develop an oral chronotherapeutic drug delivery system containing anti-asthmatic drugs. In the first phase, effect of various types of cellulose derivative polymers in the presence of Mg stearate as a coating material was studied by using Taguchi design of experiment with theophylline anhydrous as a model drug. HPMC K100, HPC, NaCMC and HEC were included as hydrophilic polymers and EC as hydrophobic polymer in the presence or absence of Mg stearate. According to the statistical prediction, the optimal values obtained were: HPC for type of hydrophilic polymer, hydrophilic polymer/EC ratio in the range of 2.5: 1 to 4: 1 and Mg stearate in the range of 26-30mg. Since, the results from optimization studies were found to be in wider range and suggested further studies to arrive at the optimal settings. Hence in the second phase, a D-optimal design of experiment was employed to identify the optimal composition of ternary blend of EC, HPC and Mg stearate as outer coating material. As response variables % drug release at 8hr, % drug release at 10hr and time required in hr for 10% of drug release (lag time) were considered. The design was quantitatively evaluated by quadratic model and the results of statistical analysis revealed that the interaction factors between EC-HPC and HPC-Mg stearate were found to be highly significant on the studied response variables. In the third phase, the effects of pH, time and enzyme dependent polymers as coating materials were evaluated for formula composition in the preparation of press-coated tablets containing theophylline anhydrous as a model drug by using D-optimal design of experiment.
Pagination: xv, 161p.
Appears in Departments:Faculty of Pharmaceutical Sciences

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01_title.pdfAttached File47.39 kBAdobe PDFView/Open
02_declaration.pdf84.73 kBAdobe PDFView/Open
03_certificates.pdf1.8 MBAdobe PDFView/Open
04_acknowledgements.pdf88.31 kBAdobe PDFView/Open
05_abstract.pdf109.45 kBAdobe PDFView/Open
06_table of contents.pdf79.37 kBAdobe PDFView/Open
07_list of tables figures & plates.pdf123.58 kBAdobe PDFView/Open
08_list of abbreviations.pdf61.11 kBAdobe PDFView/Open
09_chapter 1.pdf98.43 kBAdobe PDFView/Open
10_chapter 2.pdf162.13 kBAdobe PDFView/Open
11_chapter 3.pdf89.77 kBAdobe PDFView/Open
12_chapter 4.pdf188.51 kBAdobe PDFView/Open
13_chapter 5.pdf5.34 MBAdobe PDFView/Open
14_chapter 6.pdf214.59 kBAdobe PDFView/Open
15_chapter 7.pdf96.58 kBAdobe PDFView/Open
16_chapter 8.pdf143.69 kBAdobe PDFView/Open
17_list of publications.pdf99.08 kBAdobe PDFView/Open

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