Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/3465
Title: Designing fabrication and evaluation of controlled drug delivery systems of some potential anti diabetic drugs using synthetic and natural polymers
Researcher: Ahad, Hindustan Abdul
Guide(s): Himabindu, V
Keywords: Pharmaceutical Sciences
Drug delivery systems
Anti diabetic drugs
Polymers
Upload Date: 19-Apr-2012
University: Jawaharlal Nehru Technological University
Completed Date: August, 2011
Abstract: The main objects of the present study was to develop a formulation with increase in therapeutic efficacy, reduce frequency of administration and improve patient compliance, by developing controlled release matrix tablets and matrix type transdermal patches of Glipizide, Glimepiride with synthetic and natural polymers. This work aims at investigating and formulating controlled release matrix tablets and matrix type transdermal patches of anti-diabetic drugs(Glipizide and Glimepiride) using easily available and economical polymers. The matrix tablets were prepared with various ratios of synthetic (Povidone) and natural (Aloe barbadensis miller leaf mucilage and Guar gum) polymers. The matrix transdermal patches were prepared with various ratios of synthetic (Povidone) and natural (fruit mucilage of Ficus bengalensis, Ficus carica and Ficus glomerata) polymers. Since scare attempts has been made on Aloe barbadensis miller leaf mucilage as controlled releasing polymer for developing matrix tablets. So, physicochemical characterization of Aloe barbadensis miller has made for reproducibility of results. Since no attempts has been made on Ficus bengalensis, Ficus carica and Ficus glomerata fruit mucilages as controlled releasing polymer for developing transdermal patches. So, physicochemical characterization of Ficus bengalensis, Ficus carica and Ficus glomerata has made for reproducibility of results. These natural polymers (Aloe barbadensis miller leaf mucilage, Ficus bengalensis, Ficus carica and Ficus glomerata fruit mucilage) in addition to controlled releasing properties have proven anti diabetic properties. Hence the author has selected these in his research.
Pagination: xxvi, 296p.
URI: http://hdl.handle.net/10603/3465
Appears in Departments:Faculty of Pharmaceutical Sciences

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01_title.pdfAttached File22.23 kBAdobe PDFView/Open
02_dedication.pdf213.99 kBAdobe PDFView/Open
03_certificate.pdf146.53 kBAdobe PDFView/Open
04_acknowledgements.pdf169.55 kBAdobe PDFView/Open
05_abstract.pdf172.62 kBAdobe PDFView/Open
06_orientation of the thesis.pdf167.58 kBAdobe PDFView/Open
07_table of contents.pdf225.54 kBAdobe PDFView/Open
08_list of tables.pdf308.13 kBAdobe PDFView/Open
09_list of figures.pdf278.91 kBAdobe PDFView/Open
10_glossary of symbols.pdf179.17 kBAdobe PDFView/Open
11_abbreviations.pdf173.53 kBAdobe PDFView/Open
12_chapter 1.pdf569.55 kBAdobe PDFView/Open
13_chapter 2.pdf540.09 kBAdobe PDFView/Open
14_chapter 3.pdf509.27 kBAdobe PDFView/Open
15_chapter 4.pdf5.02 MBAdobe PDFView/Open
16_chapter 5.pdf362.75 kBAdobe PDFView/Open
17_chapter 6.pdf304.71 kBAdobe PDFView/Open
18_references.pdf383.17 kBAdobe PDFView/Open
19_list of publications.pdf303.64 kBAdobe PDFView/Open


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