Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/3453
Title: Formulation and evaluation of oral controlled release dosage forms of some anti viral drugs
Researcher: Padala, Narayana Raju
Guide(s): Narasu, M Lakshmi
Katakam, Prakash
Keywords: Pharmaceutical Sciences
Acquired Immune Deficiency Syndrome
HIV/AIDS
Drug delivery systems
Upload Date: 19-Apr-2012
University: Jawaharlal Nehru Technological University
Completed Date: March, 2011
Abstract: Human Immunodeficiency Virus (HIV) infection and Acquired Immune Deficiency Syndrome (AIDS), commonly referred to as HIV/AIDS, constitute one of the most serious infectious disease challenges to public health globally, and has had a crippling effect in certain parts of the world. There are currently 33.2 million people living with HIV/AIDS globally. The people suffering with HIV infection need to take more number of drugs with repeated administration. This is because of the structural changes of the viral gene inside the cell and less biological half lives of these drugs. This causes the patient non compliance and some time may lead to the severe adverse affects. Sustaining the drug release of these drugs may improve the patient compliance, reduce the plasma drug fluctuations and limit the adverse reactions. In the present study three anti retroviral drugs such as lamivudine, zidovudine and stavudine were selected to develop the extended release formulations using various rate controlled polymers such as cellulose derivatives, methylacrylates, carbopols and polyethylene oxides. Formulations and processing parameters were developed and optimized in order to achieve the desirable rate of drug release from each drug delivery system. Various physic chemical properties for the matrix tablets, granules and microcapsules were studied with an aim to commercialize final product. In vitro dissolution and in vivo bioavailability studies were conducted on selected formulations. Accelerated stability studies on some selected formulations were conducted as per ICH guidelines. This research study provided useful information on preformulation and formulation optimization of three anti retroviral drugs during development of controlled drug delivery systems containing various rate controlling polymers.
Pagination: 270p
URI: http://hdl.handle.net/10603/3453
Appears in Departments:Faculty of Pharmaceutical Sciences

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01_title.pdfAttached File146.21 kBAdobe PDFView/Open
02_dedication.pdf9.64 kBAdobe PDFView/Open
03_declaration.pdf106.02 kBAdobe PDFView/Open
04_certificates.pdf248.37 kBAdobe PDFView/Open
05_acknowledgements.pdf77.95 kBAdobe PDFView/Open
06_contents.pdf280.6 kBAdobe PDFView/Open
07_list of tables.pdf177.79 kBAdobe PDFView/Open
08_list of figures.pdf213.08 kBAdobe PDFView/Open
09_abbreviations.pdf112.02 kBAdobe PDFView/Open
10_list of publications.pdf167.95 kBAdobe PDFView/Open
11_abstract.pdf75.41 kBAdobe PDFView/Open
12_chapter 1.pdf262.43 kBAdobe PDFView/Open
13_chapter 2.pdf357.32 kBAdobe PDFView/Open
14_chapter 3.pdf191.17 kBAdobe PDFView/Open
15_chapter 4.pdf1.12 MBAdobe PDFView/Open
16_chapter 5.pdf1.07 MBAdobe PDFView/Open
17_chapter 6.pdf871.89 kBAdobe PDFView/Open
18_chapter 7.pdf450.98 kBAdobe PDFView/Open
19_chapter 8.pdf128.79 kBAdobe PDFView/Open
20_references.pdf213.58 kBAdobe PDFView/Open


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