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Title: Oral Nanoparticulate Colon Specific Drug Delivery System of Metronidazole and Tinidazole in the Treatment of Amoebiasis
Researcher: Senthil Prabhu R
Guide(s): Rajendran N N
Keywords: Amoebiasis
Drug Delivery System
Oral Nanoparticulate Colon
University: The Tamil Nadu Dr. M.G.R. Medical University
Completed Date: 2011
Abstract: The present study was aimed to develop and evaluate oral nanoparticulate colon specific drug delivery of metronidazole (MTZ) and tinidazole (TNZ) in the treatment of amoebiasis. Management of amoebiasis continues to be challenging with the currently available drug delivery systems due to poor bioavailability by the oral route or efficacy is some time limited or toxicity can be severe and drug resistance can be a problem. These limitations necessitate urgent requirement of novel drugs which do not suffer from such problems. MTZ and TNZ are the drugs of choice for the treatment of intestinal amoebiasis and have been used successfully for more than four decades. Reported side effects are anorexia, nausea, vomiting, malaise, metallic taste, diarrohoea, drowsiness, headache, sleep disturbance and potential teratogenicity. (Astelbauer et al., 2011). Currently these drugs are administered orally as tablets and suspensions. These delivery systems are disadvantageous that they fail to reach the colon in a concentration sufficient enough to effectively eradicate local infection in the colon, besides, these systems often result in systemic side effects and so necessitates newer drug delivery strategy to overcome these disadvantages. Nanoparticulate drug delivery systems appear to be promising for improving bioavailability of drugs. Conclusion: The present study demonstrates the beneficial effects of nanoparticulate delivery of MTZ and TNZ to the colon for improved anti amoebic activity of the drugs that circumvent the systemic side effects associated with conventional delivery system. The polymers EL 100, ES 100, PLA and PLGA appear promising for development of nanoparticles for specific colonic delivery of MTZ and TNZ for intestinal amoebiasis. EL 100 and ES 100 in combination was found to have better control on drug release as compared to PLA and PLGA. A further detailed study in humans is recommended for the feasibility of nanoparticulate delivery approach with improved therapeutic efficacy for intestinal amoebiasis.
Pagination: 218
Appears in Departments:Department of Pharmacy

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01_title.pdfAttached File72.66 kBAdobe PDFView/Open
02_certificate.pdf52.06 kBAdobe PDFView/Open
03_preliminary pages.pdf57.98 kBAdobe PDFView/Open
04_chapter 1.pdf69.15 kBAdobe PDFView/Open
05_chapter 2.pdf296.63 kBAdobe PDFView/Open
06_chapter 3.pdf59.3 kBAdobe PDFView/Open
07_chapter 4.pdf55.13 kBAdobe PDFView/Open
08_chapter 5.pdf384.95 kBAdobe PDFView/Open
09_chapter 6.pdf328.29 kBAdobe PDFView/Open
10_chapter 7.pdf2.83 MBAdobe PDFView/Open
11_references.pdf104.71 kBAdobe PDFView/Open
12_annexure.pdf142.06 kBAdobe PDFView/Open
80_recommendation.pdf125.54 kBAdobe PDFView/Open

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