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Researcher: Santhi, M
Guide(s): Uma Sekar, Dr
Upload Date: 30-Dec-2014
University: Sri Ramachandra University
Completed Date: 2014
Abstract: Antibiotic resistance is a major concern of contemporary medicine. The newlinecontinuing emergence of resistant organisms that cause nosocomial infections newlinecontribute substantially to the morbidity and mortality of hospitalized patients. newlineExtensive data indicate that the intensive care units (ICU) are the epicenter for the newlinespawning multidrug resistance within hospitals, since patients in ICU undergo newlineinvasive procedures, treatment with antibiotic combinations and greater chance of newlineexposure to resistant pathogens [Paramythiotou et al.2004]. Increase in antibiotic newlineresistance, among Gram negative bacteria is a notable example of how bacteria can newlineprocure, maintain and express new genetic information that can confer resistance to newlineone or several antibiotics. This increase has prompted calls for infection control newlinemeasures to curb their dissemination. [Walsh et al. 2005] newlineThe advent of carbapenems in the 1980s heralded a new treatment option for newlineserious bacterial infections. The most commonly use carbapenems include imipenem, newlinemeropenem, ertapenem and doripenem. Of the many hundreds of different and#946;-lactams, newlinecarbapenems possess the broadest spectrum of activity and greatest potency against newlineGram-negative bacteria. As a result, they are often used as last-line agents or newline antibiotics of last resort . They are reliably active against multidrug-resistant Gramnegative newlinebacteria and form the mainstay in the treatment of serious infections in most newlinehospitals across the world today. These antibiotics are stable to and#946; -lactamases newlineincluding the extended spectrum and#946; -lactamases (ESBLs) and Amp C produced by newlinegram negative bacilli (GNB). [Wallace et al.2011] newline
Pagination: 1-250
Appears in Departments:Medical College

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