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Title: Evaluation of efficacy and safety of bone marrow aspirate concentrate coated hydroxyapatite and unfractionated bone marrow aspirate coated hydroxyapatite in reconstruction of post enucleation mandibular defects
Researcher: Raja Sekhar. Gali
Guide(s): Ravindran C
Keywords: Clinical Medicine
Clinical Pre Clinical and Health
Dentistry Oral Surgery and Medicine
University: Sri Ramachandra Institute of Higher Education and Research
Completed Date: 2020
Abstract: The aim of this study was to compare and evaluate bone regeneration between bone marrow aspirate concentrate coated hydroxyapatite and unfractionated /whole bone marrow aspirate coated hydroxyapatite when used for reconstruction of post enucleation mandibular defects The primary objective was to evaluate bone regeneration between these two groups of patients by clinical and radiologic methods Histologic evaluation was performed as an adjuvant in two patients in each group to qualitatively assess bone regeneration and resorption of hydroxyapatite at the end of nine months follow up period Patients and Methods: Eligible patients were randomly allocated in to BMAC n equal to 18 and BMA n equal to 18 groups as per simple computer generated randomization chart All patients underwent enucleation of primary mandibular pathologies under general anesthesia followed by reconstruction of post enucleation defects in the same operative session using synthetic multiphasic hydroxyapatite and tricalcium phosphate blocks that were soaked in unfractionated bone marrow aspirate group) and concentrated bone marrow aspirate In the BMAC group concentration of bone marrow aspirate was performed with in operating room itself using density gradient centrifugation All the patients were followed up for a period of nine months post operatively at intervals of immediate 136 and 9 months Two patients in BMA group and one patient in BMAC group had partial wound dehiscence during early post operative period less than 1 month that were managed by local wound care methods At nine months poste operative all the patients had clinical evidence of good oral mucosal healing Sequential changes of bone density at the grafted site measured using grey scale-level histogram showed an increase in mean grey values because of radio opaque nature of hydroxyapatite This was followed by a trend of decrease in radiodensity suggestive of graft resorption Sixth and ninth month follow up showed a steady increase in radiodensity suggestive of new bone formation Sim
Pagination: 1-141
Appears in Departments:Dental College

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80_recommendation.pdfAttached File254.74 kBAdobe PDFView/Open
appendices.pdf7.23 MBAdobe PDFView/Open
certificate page.pdf1.05 MBAdobe PDFView/Open
chapter 1 introduction.pdf264.11 kBAdobe PDFView/Open
chapter 2 review of literature.pdf324.98 kBAdobe PDFView/Open
chapter 3 aim and objectives.pdf67.54 kBAdobe PDFView/Open
chapter 4 methodology.pdf1.64 MBAdobe PDFView/Open
chapter 5 results.pdf577.3 kBAdobe PDFView/Open
chapter 6 discusson.pdf175.68 kBAdobe PDFView/Open
chapter 7 summary and conclusion.pdf198.59 kBAdobe PDFView/Open
index page.pdf238.4 kBAdobe PDFView/Open
references.pdf225.58 kBAdobe PDFView/Open
title page.pdf275.83 kBAdobe PDFView/Open

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