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Title: Pharmacokinetic study on the Siddha Polyherbal formulation Madhumega Chooranam mmc in preclinical and in clinical settings
Researcher: Anbarasi C
Guide(s): Thanikachalam S
Keywords: Clinical Medicine
Clinical Pre Clinical and Health
Medicine Research and Experimental
University: Sri Ramachandra Institute of Higher Education and Research
Completed Date: 2020
Abstract: The aim is to study the pharmacokinetic of the Siddha polyherbal formulation Madhumega Chooranam The standardization of the study drug was carried out before initiating the preclinical animal study in rabbits and clinical study in healthy human volunteer adhering to the AYUSH GCP guidelines The standardization of the Siddha polyherbal formulation Madhumega Chooranam revealed the following results. The pharmacognostic authentication of the drug was carried according to Siddha Pharmacopoeia of India, for macroscopic and microscopic analysis The macroscopic analysis showed that the Madhumega Chooranam is a greenish brown fine powder with aromatic odour and astringent taste The powder microscopy features of Madhumega Chooranam ensured the presence of the seven herbs contained in it. The physicochemical analysis of study drug showed the moisture content was 8 point 44 percentage ash content was 6 point 39 percentage acid in soluble ash was 2 point 75 percentage alcohol soluble extractives was 24 point 85 percentage water soluble extractive 25 point 35 percentage The qualitative phytochemical analysis showed high amount of tannins glycosides steroids phenols alkaloids less amount of carbohydrates reducing sugars proteins flavones saponins triterpenoids and absence of quinones and anthroquinones The total phenolic content was estimated as 2 point 69 percentage flavanoids was 0 point 45 percentage and total tannins was 0 point 85 percentage The invitro antioxidant activity was carried out for the study drug as increased production of free radicals especially reactive oxygen species was currently suggested as mechanism underlying diabetes and diabetic complications The total antioxidant activity of MMC was better than the standard The gallic acid was chosen as a marker for the preclinical and clinical pharmacokinetic study based on the literature evidences The gallic acid content in the Madhumega Chooranam was estimated as 6 point 008 percentage by the HPLC instrument The content of Gallic acid was determined by using e
Pagination: 1-124
Appears in Departments:College of Pharmacy

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