Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/294527
Title: Effect of turmeric supplementation on pharmacokinetics of paclitaxel in breast cancer patients A pharmacometrics study
Researcher: Kalluru Hindu
Guide(s): Mangathayaru K
Keywords: Clinical Pre Clinical and Health
Pharmacology and Pharmacy
Pharmacology and Toxicology
University: Sri Ramachandra Institute of Higher Education and Research
Completed Date: 30/06/2020
Abstract: Usage of herbal supplements by cancer patients in combination with their conventional therapies is widely reported for different reasons such as reducing side effects of chemotherapy slowing progression of cancer and improving quality of life Turmeric Curcuma longa is one of the most commonly used herbal supplement in cancer In vitro and In vivo data on animals indicate that Turmeric effects CYP450 enzymes and drug transporters thus hypothesized to bring about pharmacokinetic interaction with co-administering drug Therefore the objective of this study is to detect clinical pharmacokinetic herb drug interactions of Turmeric with Paclitaxel commonly prescribed anticancer agent in breast cancer This is a prospective study totally 60 breast cancer patients on treatment with Paclitaxel and turmeric were enrolled Four blood samples will be collected from the patients at the end of infusion of the Paclitaxel chemotherapy at two adjacent cycles first time without the concomitant administration of Turmeric first cycle and the second time is with the concomitant administration of Turmeric second cycle The collected blood samples will be appropriately processed and quantified for Paclitaxel using a validated RPHPLC method The sparse concentration time was subjected to pharmacomentrics and generated full concentration time profiles of each patient using NONMEM Pharmacokinetic parameters of paclitaxel were estimated before and after turmeric administration using Non compartmental analysis Parallely quality of life and hematological profile of the patients were also estimated Pharmacokinetics parameters and Cmax of paclitaxel were found to be decreased on turmeric supplementation Quality of life and hematological profile of the patients were found to be increased The study concludes that the turmeric supplementation has significantly altered the pharmacokinetic profile of paclitaxel It has also improved the quality of life and hematological profile in the study participants within a short period of 21 days newline
Pagination: 1-114
URI: http://hdl.handle.net/10603/294527
Appears in Departments:College of Pharmacy



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