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Title: Characterisation of virulence factors and beta lactamases in Klebsiella pneumoniae
Researcher: Remya P.A
Guide(s): Uma Sekar
Keywords: Clinical Medicine
Clinical Pre Clinical and Health
Medicine Research and Experimental
University: Sri Ramachandra Institute of Higher Education and Research
Completed Date: 24/06/2020
Abstract: Klebsiella pneumoniae causes a wide spectrum of infections in humans. Different strains of K.pneumoniae may express a variety of virulence factors that allow them to overcome the host immune response. Resistance to beta-lactams has impacted the empirical treatment of infections caused by them This study was undertaken to understand the occurrence and distribution of virulence factors in clinical isolates of K.pneumoniae and to gain insights into the relationship with type of disease and antimicrobial resistance pattern The study was conducted in a tertiary care centre Institutional Ethics approval was obtained A total of 370 clinically significant consecutive non duplicate isolates collected from September 2014 to June 2015 were included in this study Phenotypic and genotypic methods were performed as per standard recommended protocols to detect the various virulence factors and beta-lactamases in K pneumoniae Clinical isolates of Klebsiella pneumoniae carry a variety of virulence genes ranging from one to nine This is the second report of hvKP from India and the first about hypervirulent K2A gene positive K.pneumoniae harbouring ESBLs and carbapenemase encoding genes EntB and FimH are the most common genes contributing to pathogenicity Several virulence factors contribute to single clinical entity while a single virulence factor can be associated with multiple conditions 58 point 91 percent K pneumoniae produced ESBLs 9 percent AmpC and 13 point 7 percent were carbapenemase producers Pathogenic K pneumoniae is clonally diverse Multiple clones are encountered in both ICU and non-ICU setting of the hospital There is no clear association between mortality and virulence factors or antimicrobial resistance newline
Pagination: 1-130
Appears in Departments:Medical College

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80_recommendation.pdfAttached File43.03 kBAdobe PDFView/Open
certificate declaration.pdf317.09 kBAdobe PDFView/Open
chapter 1 introduction.pdf304.76 kBAdobe PDFView/Open
chapter 2 review of literature.pdf527.95 kBAdobe PDFView/Open
chapter 3 aims and objetives.pdf180.42 kBAdobe PDFView/Open
chapter 4 materials and methods.pdf620.49 kBAdobe PDFView/Open
chapter 5 results.pdf1.18 MBAdobe PDFView/Open
chapter 6 discussion.pdf435.06 kBAdobe PDFView/Open
chapter 7 summary.pdf306.64 kBAdobe PDFView/Open
chapter 8 conclusions.pdf194.15 kBAdobe PDFView/Open
preliminary pages.pdf333.38 kBAdobe PDFView/Open
references.pdf532.11 kBAdobe PDFView/Open
title page.pdf112.38 kBAdobe PDFView/Open

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