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Title: Design and evaluation of modified drug release multiparticulate drug delivery systems
Researcher: Pallavi M Chaudhari
Guide(s): Pravin D Chaudhari
Keywords: Clinical Pre Clinical and Health
Drug delivery systems
Pharmacology and Pharmacy
Pharmacology and Toxicology
University: Jawaharlal Nehru Technological University, Hyderabad
Completed Date: 2015
Abstract: As oral route has been used widely for most of the drugs, as it potentiates easy administration, patient compliance. During few decades modified drug delivery system in form of multiparticulates has gain wide importance due to its advantages over conventional dosage forms. So, the plan of current study was to devise modified multiparticulate oral drug delivery systems of Salbutamol sulphate and Gliclazide by use of different techniques with diverse approaches. The Salbutamol sulphate pellets were prepared by solution layering technique and extrusion spheronization techniques, while Gliclazide pellets were prepared only by extrusion spheronization technique. Then the prepared pellets were filled into capsules, as final dosage form. The resulting pellets were evaluated for different in vitro and in-vivo evaluation parameters like drug content, pellet size, drug release, and morphological studies. From the studies it revealed that Eudragit polymers like Eudragit RSPO, Eudragit NE 30D as well as pectin can be utilized for modifying the release of the drugs. The interaction study between drug and polymer was as well studied by means of performing Fourier transform infra red and Differential scanning calorimetry test. To judge the stability of all formulated pellets, short time stability study of the chosen batches were carried out by maintaining them at 40°C ±2°C and 75% ± 5% RH for a period of six months. The groundwork studies were initiated to set the selection of polymer, polymer ratio, cross linking time and the concentration of cross linking agent etc for different approaches. In in-vitro studies, it was newlineobserved that selection of polymer and its concentration played an important role in formulation of pellets. From scanning electron morphology study, it was observed that, the formed pellets were spherical. The FTIR and DSC study revealed the compatibility of drug with different polymers.
Pagination: 175p.
Appears in Departments:Faculty of Pharmaceutical Sciences

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01_title.pdfAttached File227.35 kBAdobe PDFView/Open
02_declaration.pdf144.53 kBAdobe PDFView/Open
03_certificate.pdf302.19 kBAdobe PDFView/Open
04_acknowledgement.pdf247.33 kBAdobe PDFView/Open
05_abstract.pdf125.04 kBAdobe PDFView/Open
06_contents.pdf280.65 kBAdobe PDFView/Open
07_list_of_tables_figures.pdf246.75 kBAdobe PDFView/Open
08_chapter_1.pdf294.09 kBAdobe PDFView/Open
09_chapter_2.pdf354.31 kBAdobe PDFView/Open
10_chapter_3.pdf203.21 kBAdobe PDFView/Open
11_chapter_4.pdf436.3 kBAdobe PDFView/Open
12_chapter_5.pdf3.07 MBAdobe PDFView/Open
13_chapter_6.pdf211.13 kBAdobe PDFView/Open
14_chapter_7.pdf160.13 kBAdobe PDFView/Open
15_bibliography.pdf220.59 kBAdobe PDFView/Open
80_recommendation.pdf374.72 kBAdobe PDFView/Open

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