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Title: Efficacy and safety administration of lacosamide in the treatment of refractory partial epilepsy in pediatric patients
Researcher: Ismail Pasha
Guide(s): Suresh D.K.
Keywords: Clinical Pre Clinical and Health,Pharmacology and Toxicology,Pharmacology and Pharmacy
University: Jawaharlal Nehru Technological University, Hyderabad
Completed Date: 2015
Abstract: A single centre, prospective study was performed to investigate the efficacy and safety of lacosamide as add on therapy in pediatric patients with refractory partial epilepsy.The study was done at Dr. Prabhakar Kore, tertiary care hospital over a period of 30 months duration from Nov 2011 to May 2014. Seventy-nine newlinepatients with refractory partial epilepsy (age 5 - 15 years), who had not newlineresponded to more than 2 antiepileptic medications and in whom lacosamide newlinewas used as add on drug were enrolled. Lacosamide tablets were administered newlineorally, for one week at a dose of 25 mg twice a day followed by 50 mg twice newlinedaily for the remaining period. Efficacy, safety and tolerability was assessed newlineduring titration (one month), treatment phase (three months), and subsequent newlinetwo follow up visits of one month each. Liver function tests (SGOT and SGPT) newlineand EEG were done before enrollment and at the end of treatment period. Patient s care takers or principal investigator observed for any adverse events and recorded the data in the predesigned adverse event form. newline
Appears in Departments:Faculty of Pharmaceutical Sciences

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01_title.pdfAttached File170.21 kBAdobe PDFView/Open
02_declaration.pdf279.32 kBAdobe PDFView/Open
03_certificate.pdf854.22 kBAdobe PDFView/Open
04_acknowledgement.pdf166.48 kBAdobe PDFView/Open
05_abstract.pdf184.63 kBAdobe PDFView/Open
06_contents.pdf213.07 kBAdobe PDFView/Open
07_list of tables and figures.pdf165.48 kBAdobe PDFView/Open
08_chapter 1.pdf266.19 kBAdobe PDFView/Open
09_chapter 2.pdf131.2 kBAdobe PDFView/Open
10-chapter 3.pdf742.21 kBAdobe PDFView/Open
11-chapter 4.pdf376.62 kBAdobe PDFView/Open
12-chapter 5.pdf1.53 MBAdobe PDFView/Open
13-chapter 6.pdf435.89 kBAdobe PDFView/Open
14-chapter 7.pdf192.53 kBAdobe PDFView/Open
15-chapter 8.pdf152.23 kBAdobe PDFView/Open
16-bibliography.pdf242.64 kBAdobe PDFView/Open

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