Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/286924
Title: A study on role Of COL 2 A1 Gene Vvriable number of Tandem Repeats VNTR Polymorphism in susceptibility to Dental Flourosis in Salem District Tamil Nadu
Researcher: Maya Ramesh
Guide(s): Rita Mary Aruna
Keywords: Clinical Pre Clinical and Health,Clinical Medicine,Dentistry Oral Surgery and Medicine
University: Sri Ramachandra Institute of Higher Education and Research
Completed Date: 02/03/2020
Abstract: Dental fluorosis occurs especially during the period of teeth development The aim of the study was to evaluate the fluorosis status in an endemically fluorosed district of Salem in Tamil Nadu and also to investigate the role of COL2 A 1 gene VNTR polymorphism in the susceptibility to dental fluorosis Prevalence of dental fluorosis among 4989 school children in Salem was done 300 extracted premolar teeth were collected from the patients with and without fluorosis who came for orthodontic correction The allelic ratio of DNA after isolation was subsequently determined for each marker by Gene marker software Dental fluorosis was present in 56 point 9 percentage of children The water fluoride level was found to be between 0 and 3 ppm Genotyping of the COL2A1 VNTR gene in the study population showed the presence of 6 alleles and revealed 15 genotype combinations This research represents the first published report of an association between a VNTR polymorphism of COL2 A1gene and differential susceptibility of dental fluorosis in humans These types of research will enable us to identify individuals at increased risk for dental fluorosis Dental fluorosis VNTR Genetic polymorphism Collagen COL2A1gene Fluoride level Variable number of Tandem repeats newline
Pagination: 1-200
URI: http://hdl.handle.net/10603/286924
Appears in Departments:Dental College

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annexures.pdfAttached File1.27 MBAdobe PDFView/Open
bibliogrphy.pdf305.5 kBAdobe PDFView/Open
certificate page.pdf1.62 MBAdobe PDFView/Open
chapter 1 introduction.pdf449.04 kBAdobe PDFView/Open
chapter 2 review of literature.pdf429.16 kBAdobe PDFView/Open
chapter 3 materials and methods.pdf963.13 kBAdobe PDFView/Open
chapter 4 results.pdf921.09 kBAdobe PDFView/Open
chapter 5 dicussion.pdf325.6 kBAdobe PDFView/Open
chapter 6 conclusion.pdf270.63 kBAdobe PDFView/Open
preliminary pages.pdf112.27 kBAdobe PDFView/Open
title page.pdf155.36 kBAdobe PDFView/Open


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