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Title: Fabricated approach for an effective wound dressing material based on a natural polymer impregnated with Acalypha indica extract
Researcher: Preethi Jenifer S
Guide(s): Mangathayaru K
Keywords: Clinical Pre Clinical and Health,Pharmacology and Toxicology,Pharmacology and Pharmacy
University: Sri Ramachandra Institute of Higher Education and Research
Completed Date: 20/02/2020
Abstract: Guar based nanofibers and thin films incorporated with 3 different percentages of newlineAcalypha indica were successfully developed by electrospinning and solvent casting newlinemethod for potential application in wound healing Fourier Transform Infrared newlineFTIR Spectroscopy was done to determine the functional group interactions newlinebetween the polymer and Acalypha indica 2D and 3D surface morphological evaluation newlinethermal behaviours contact water angle measurement swelling capability and newlinemechanical strength were performed to determine the ideal dressing The antimicrobial test newlineHDF proliferation assay and Calcein AM staining assay was performed for the newlinepreferred nanofibers and thin films which surpassed the characterizations necessary for newlinean ideal dressing In vivo evaluation on male wistar rats were carried out to determine newlinethe efficacy of the wound dressing on excisional model. Results showed that PB5Ai newlinenanofiber and thin film had nano smooth and hydrophilic surface morphology with newlineadequate mechanical strength for skin applications Swelling study demonstrated the newlineinsolubility of the dressing for 24 h They also exhibited anti-microbial activity newlineand HDF proliferation for a period of 9 Days In vivo evaluation of the dressing on male newlinewistar rats enhanced the contraction of wounds suggesting the PB5Ai nanofiber and newlinethin film as a potential wound dressing for acute wounds newline newline
Pagination: 1-125
Appears in Departments:College of Biomedical Sciences

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