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Title: Study on bacterial lipid modification of proteins for novel protein engineering applications
Researcher: Kamalakkannan, S
Guide(s): Sankaran, K
Keywords: bacterial lipid
novel protein engineering
science and humanities
Upload Date: 3-Nov-2014
University: Anna University
Completed Date: 01/06/2005
Abstract: Many manmade applications like ELISA liposomal drug delivery newlinevaccine biosensor biosorbents and biocatalyst require proteins to perform newlinetheir functions in the solidliquid interface while anchored to solid surfaces newlineAnchoring hydrophilic proteins to hydrophobic surfaces is a major challenge newlineeven for biological systems Bacteria have overcome this challenge by newlineevolving lipoproteins to perform a variety of functions at membraneaqueous newlineinterface while one end of hydrophilic protein is anchored to its membrane by newlinea lipid moiety NacylSdiacylglyceryl cysteine the rest of the protein is in newlinethe aqueous phase functioning normally However bacterial lipid modification newlinemechanism remains unexploited for manmade applications Based on the newlinecurrent understanding of this ubiquitous and unique bacterial lipid newlinemodification it is possible to use Ecoli the popular recombinant proteinexpression newlinehost for converting a protein to a lipoprotein with the newlinecharacteristic hydrophobic anchor at the Nterminal end newline newline
Pagination: xxiv, 197p.
Appears in Departments:Faculty of Science and Humanities

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01_title.pdfAttached File12.84 kBAdobe PDFView/Open
02_certificate.pdf5.25 kBAdobe PDFView/Open
03_abstract.pdf11.05 kBAdobe PDFView/Open
04_acknowledgement.pdf10.08 kBAdobe PDFView/Open
05_contents.pdf37.26 kBAdobe PDFView/Open
06_chapter 1.pdf324.61 kBAdobe PDFView/Open
07_chapter 2.pdf267.78 kBAdobe PDFView/Open
08_chapter 3.pdf229.74 kBAdobe PDFView/Open
09_chapter 4.pdf177.68 kBAdobe PDFView/Open
10_references.pdf68.35 kBAdobe PDFView/Open
11_publications.pdf6.76 kBAdobe PDFView/Open
12_vitae.pdf5.94 kBAdobe PDFView/Open

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