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Title: Synthesis and Studies on Quinoline Acridine Based Heterocycles
Researcher: Jyothish kumar.L
Guide(s): Vijaya kumar.V
Keywords: Physical Sciences,Chemistry,Chemistry Multidisciplinary
University: VIT University
Completed Date: 2019
Abstract: We have reported the synthesis of 3-acetyl-4-phenyquinoline/acridine based newlineenaminone and its derivatives using DMFDMA as a building block. And also newlinesynthesis of 3-acetyl-4-phenylquinoline based pyrazole, isoxazole, pyrimidin, phenyl newlineamino-prop-2-en-1-one, pyridin-2-yl-amino-prop-2-en-1-one, 2-methylpyridine-3- newlinecarboxylatederivatives using hydrazine, hydroxylamine, guanidine hydrochloride, newlineaniline, 2-amino pyridine, and ethylacetoacetate as building block by solvent-free newlinereaction condition under microwave irradiations and conventional process. All the newlinecompounds were characterized by spectroscopic techniques like 1H NMR, 13C NMR, newlineDEPT-135, H, H-COSY, HSQC and mass spectrometry (HR-MS). These newly newlinesynthesized analogues have shown excellent to good antibacterial, antifungal and newlineantioxidant activity. newlineCompounds containing amide bond in 3-acetyl-4-phenylquinoline can be prepared by newlineusing coupling reagents such as EDC, HATU and DCC in presence of DIEPA as a newlinebase in DMF. All the synthesized compounds were characterized by NMR and mass newlinespectral data and then tested for in vitro antibacterial, antifungal, antioxidant and newlineantidiabetic activity. newlineSimilarly we synthesized different sulfonamides by chosen 3-acetyl-4- newlinephenylquinoline containing primary amine as one of the starting material in THF. The newlineproducts were characterized through spectral data and screened for their in vitro newlineantibacterial, antifungal, antioxidant activities and antidiabetic activity. newline
Pagination: I-XVII,1-244
Appears in Departments:School of Advanced Sciences

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01_ tittle.pdfAttached File59.17 kBAdobe PDFView/Open
03_abstract.pdf75.41 kBAdobe PDFView/Open
04_acknowledgement.pdf83.93 kBAdobe PDFView/Open
05_tables of contents.pdf142 kBAdobe PDFView/Open
06_list of figures.pdf190.56 kBAdobe PDFView/Open
07_list of tables.pdf99.54 kBAdobe PDFView/Open
08_list of schemes.pdf77.29 kBAdobe PDFView/Open
09_list of terms and abbreviations.pdf77.03 kBAdobe PDFView/Open
10_chapter 1.pdf406.92 kBAdobe PDFView/Open
11_chapter 2.pdf7.56 MBAdobe PDFView/Open
12._chapter 3.pdf175.23 kBAdobe PDFView/Open
13_ chapter 3a.pdf3.41 MBAdobe PDFView/Open
14_chapter 3b.pdf2.06 MBAdobe PDFView/Open
15._chapter 4.pdf4.41 MBAdobe PDFView/Open
16_chapter 5.pdf101.6 kBAdobe PDFView/Open
17_ references.pdf204.3 kBAdobe PDFView/Open
18_ list of publications.pdf94.37 kBAdobe PDFView/Open

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