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Title: Investigation of the Effect of Rutin on Type II Diabetes Mellitus Associated Neurological Complications
Researcher: Prashar, Arun
Guide(s): Malairaman, Udayabanu
Keywords: Chronic Unpredicted Stress
Clinical Pre Clinical and Health,Pharmacology and Toxicology,Pharmacology and Pharmacy
Insulin Resistance
Type II Diabetes Mellitus
University: Jaypee University of Information Technology, Solan
Completed Date: 2019
Abstract: Diabetes mellitus (DM) is a chronic metabolic disorder characterized by chronic, consistent andprolonged hyperglycemia. Diabetes is associated with neurological complications likeneurodegeneration, cognitive decline, dementia and even disorders like Alzheimer s andParkinson s. Our previous work elucidated a high quantity of rutin in Urtica dioica leaf extract,which showed pronounced neuroprotection against diabetes and depression. So, we aimed toexplore the neuroprotective effects of rutin against type 2 diabetes (T2DM) mellitus associatedneurological complications. We further aim to identify the role of insulin signaling in brainduring T2DM and the effect of rutin treatment on it. newlineOur first objective was to study the neurological complications of chronic diabetes and the effectof rutin in it. Diabetes was induced using multiple low dose of streptozotocin (STZ), and treatedwith 100 mg/kg rutin for 2 months. STZ treatment led to significant hyperglycemia, glucoseintolerance and hypoinsulinemia. Diabetic animals were observed to be depressed, anxious, andshowed pronounced learning and memory deficits. These behavioral deficits were attributed tohippocampal neurodegeneration and impaired hippocampal insulin signaling. Rutin treatmentimproved hyperglycemia, glucose intolerance, attenuated hypoinsulinemia and behavioraldysfunction, and upregulated the hippocampal insulin signaling. In conclusion, rutin halts andameliorates the progression of diabetes and associated neurological complications. newlineTo better mimic the natural way of diabetes induction, our next objective was to develop aninsulin resistant state, as observed in T2DM. For this we employed a 21 day chronic unpredictedstress (CUS) induced depression paradigm, along with rutin treatment (100 mg/kg; po; od). CUSinduced pre-diabetes, insulin resistance (IR) and glucose intolerance along with similarbehavioral dysfunctions. Molecular underpinnings included hippocampal neurodegeneration andIR.
Pagination: xv, 83p.
Appears in Departments:Department of Pharmacy

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02_certificate; declaration; acknowledgement.pdf1.47 MBAdobe PDFView/Open
03_abstract; table of contents; list of tables & figures; abbr..pdf1.17 MBAdobe PDFView/Open
04_chapter 1.pdf3.08 MBAdobe PDFView/Open
05_chapter 2.pdf14.62 MBAdobe PDFView/Open
06_chapter 3.pdf532.08 kBAdobe PDFView/Open
07_chapter 4.pdf7.73 MBAdobe PDFView/Open
08_chapter 5.pdf22.04 MBAdobe PDFView/Open
09_chapter 6.pdf6.13 MBAdobe PDFView/Open
10_chapter 7.pdf1.88 MBAdobe PDFView/Open
11_chapter 8.pdf13.09 MBAdobe PDFView/Open
12_chapter 9.pdf1.54 MBAdobe PDFView/Open

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