Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/257384
Title: In vivo effects of Cleistanthin A in anaesthetised wistar rats
Researcher: Anita S
Guide(s): Sathya Subramani
Keywords: Clinical Pre Clinical and Health,Clinical Medicine,Medicine General and Internal
University: The Tamil Nadu Dr. M.G.R. Medical University
Completed Date: 2010
Abstract: Deaths due to suicide are a cause for concern worldwide. Reports from Vellore in southern India have revealed that suicide rates in India are grossly underreported. The annual suicide rate in Kaniyambadi block, Vellore district was 95.2 per 100 000 during 1994 99. This is 8 10 times higher than the reported national rate. People perceive suicide as an option to overcome interpersonal, family and financial stress among normal individuals as well as those with mental illness (S. Manoranjitham et al., 2007). Poisoning due to plant toxins are a common cause of morbidity and mortality. Their effects may vary from mild nausea to death. The aim of this study was to find out the mechanism of action of one of the active principles in Cleistanthus collinus called Cleistanthin A so that definite treatment options can be made available in cases of poisonings. This study included mostly male and few female Wistar rats of weight ranging 130-265g. They were bred and maintained in the animal house facility at CMC. The air conditioned animal house had regular day and night cycle maintenance and the rats were provided adequate food and water till they reached adequate weight and then the animals were collected for experiments. This study had 2 arms namely test and control, with 6 rats in each test arm and 4 rats in each control arm. One of the active components found in C.collinus, Cleistanthin A administered via intrapertoneal route causes respiratory arrest in rats. In the absence of statistically significanct increase in blood carbondioxide, reduction in oxygen and blood pH for both mg and and#956;g dose groups of test animals when compared to controls, no inference can be drawn about the type of acidosis in these animals. However the boxplots do indicate a trend of reduction in blood pH, increase in PCO2, decrease in PO2 and maintained bicarbonate levels in tests, suggestive of type II respiratory failure. The control rats show a trend of metabolic acidosis with hyperventilation as respiratory compensation.
Pagination: 99
URI: http://hdl.handle.net/10603/257384
Appears in Departments:Department of Medical

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02_certificate.pdf65.7 kBAdobe PDFView/Open
03_declaration.pdf163.79 kBAdobe PDFView/Open
06_chapter1.pdf81.03 kBAdobe PDFView/Open
07_chapter2.pdf93.04 kBAdobe PDFView/Open
08_chapter3.pdf13.28 kBAdobe PDFView/Open
09_chapter4.pdf101.28 kBAdobe PDFView/Open
10_chapter5.pdf613.15 kBAdobe PDFView/Open
11_chapter6.pdf167.23 kBAdobe PDFView/Open
12_chapter7.pdf17.94 kBAdobe PDFView/Open
13_references.pdf181.76 kBAdobe PDFView/Open
14_supplementary_data.pdf3.47 MBAdobe PDFView/Open


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