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Title: Studies on Leaf Extract of Selected Mangrove Species and In Vitro Evaluation of Their Bioactive Properties
Researcher: T. C . Venkateswarulu , R. Bharath Kumar
Guide(s): Gaddam Eswaraiah
University: Vignans Foundation for Science Technology and Research
Completed Date: 2019
Abstract: The mangrove vegetation is special types of community distributed in inter tidal zones of the coastal countries. The mangroves hold soil tightly and prevent soil erosion in the coastal regions. The mangrove plant extract contain wide variety of bioactive molecules and has the significance role in treating bacterial infections. The extracts of mangrove species were also used as folk medicine. In the present study, preliminary phytochemical analysis and their antimicrobial, antioxidant activities, separation of phytochemicals by Thin Layer Chromatography (TLC), identification of bioactive compounds by Gas Chromatography and Mass Spectroscopy (GC-MS) and in vitro antiproliferative activity of mangrove leaf extract are studied against MCF 7 and the HeLa cells. The methanol leaf extracts of selected mangrove species contain bioactive compounds such as terpenoids, phenols, alkaloids, flavonoids and tannins but emodin and steroids were not found in selected mangrove plant. The phytochemicals, phenols and flavonoids were found in selected mangrove species and tannins was found in only three of the selected mangroves except Lumitzera racemosa; terpenoids was found in selected mangroves except Suaeda nudiflora. The methanol leaf extracts of all the four selected mangrove species have shown antioxidant property. The maximum antioxidant activity (95.62%) was found in leaf extracts of L. racemosa at concentration 200 and#956;g/mL. The minimum antioxidant activity (37.78%) was found in the leaf extract of S. nudiflora with concentration 50 and#956;g/mL. The leaf extracted from selected mangrove leaves has shown the considerable inhibitory zones against pathogens such as Micrococcus luteus, Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis and Klebsiella pneumoniae and fungal species: Aspergillus niger and Rhizopus microsporus. The solvents such as methanol, acetone and hexane were used to extracts bioactive compounds from leaves of selected mangroves.
Pagination: 181
Appears in Departments:Department of Biotechnology

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