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Title: Bioactivity of novel glycoheterocyclic compounds
Researcher: Hemadev B
Guide(s): Ganesh Venkatraman
University: Sri Ramachandra Institute of Higher Education and Research
Completed Date: 04/05/2019
Abstract: Natural products such as alkaloids are renowned for their biological Activity but are known for their poor bioavailability and synthetic difficulty Oxindole pyrrolidines possess high antiproliferative antiprotozoal antibacterial And antiinflammatory activities Spirocyclic compounds are cyclic systems containing one carbon atom common to two rings and are present in a number of bioactive natural alkaloids Functionalized pyrrolidines pyrrolizidine and thiozolidine are the nuclear core of numerous alkaloids with significant biological properties such as anticancer activity A series of highly region selective glycoheterocyclic compounds were synthesized using 1 3dipolar cycloaddition 1 3DC method and their efficacy was tested on cell lines representing most commonly occurring cancers A 549 Lung cancer MIA PaCa 2 BxPc 3 MDA Panc 28 and CAPAN 2 Pancreatic Cancer MCF 7 and MDA MB 231 Breast cancer SCC131 Head and Neck Cancer and molecular mechanism of cell death were deciphered The results showed that among 15 compounds screened Glycopyrrolidine RP RR 210 showed the most potent anticancer activity by altering the morphology of cancer cells and induced cell cycle arrest inhibited migration caused cell death by inducing programmed cell death apoptosis through the intrinsic pathway and found to be nontoxic to HLF 1 Lung fibroblast) andAG1522 Skin Fibroblast normal cells newline
Pagination: 1-101
Appears in Departments:College of Biomedical Sciences

Files in This Item:
File Description SizeFormat 
certificate.pdfAttached File297.21 kBAdobe PDFView/Open
chapter 1 introduction.pdf540 kBAdobe PDFView/Open
chapter 2 review of literature.pdf387.66 kBAdobe PDFView/Open
chapter 3 aim and objective.pdf244.72 kBAdobe PDFView/Open
chapter 4 materials and methods.pdf1.17 MBAdobe PDFView/Open
chapter 5 results.pdf2.21 MBAdobe PDFView/Open
chapter 6 discussion.pdf387.88 kBAdobe PDFView/Open
chapter 7 conclusion.pdf361.07 kBAdobe PDFView/Open
chapter 8 references.pdf548.67 kBAdobe PDFView/Open
preliminary pages.pdf20.47 kBAdobe PDFView/Open
title page.pdf81.23 kBAdobe PDFView/Open

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