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Title: Formulation and evaluation of controlled release solid lipid microparticles of candesartan cilexetil
Researcher: Kamalakkannan V
Guide(s): Puratchikody A
Keywords: Candesartan cilexetil
Controlled release solid lipid microparticles
Solid lipid microparticles
Upload Date: 27-Aug-2014
University: Anna University
Completed Date: 01/09/2013
Abstract: Solid lipid microparticles of controlled release Candesartan cilexetil SLM 1 to SLM 12 were prepared by fusion method using different ratios of lipophilic excipients such as hydrogenated castor oil stearic acid cetostearyl alcohol and carnauba wax The drug content and in vitro drug release of the prepared Candesartan cilexetil microparticles showed favourable drug content and satisfactory drug release The formulated solid lipid microparticles were further used for the development of controlled release compressed tablets and floating tablets of Candesartan cilexetil A total of 12 formulations of compressed tablets of Candesartan cilexetil were prepared by direct compression method and evaluated for physicochemical properties and in vitro dissolution All the prepared formulations showed almost uniform mass, thickness and drug content and also indicated excellent mechanical strength The in vitro release studies of compressed tablets of Candesartan cilexetil provided that the formulations prepared with cetostearyl alcohol showed maximum drug release in a controlled manner when compared to all other formulations prepared with hydrogenated castor oil stearic acid and carnauba wax
Pagination: xxiii, 170p.
Appears in Departments:Faculty of Technology

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02_certificates.pdf3.68 MBAdobe PDFView/Open
03_abstract.pdf10.36 kBAdobe PDFView/Open
04_acknowledgement.pdf6.78 kBAdobe PDFView/Open
05_contents.pdf35.19 kBAdobe PDFView/Open
06_chapter1.pdf732.72 kBAdobe PDFView/Open
07_chapter2.pdf61.19 kBAdobe PDFView/Open
08_chapter3.pdf142.99 kBAdobe PDFView/Open
09_chapter4.pdf13.54 MBAdobe PDFView/Open
10_chapter5.pdf17.4 kBAdobe PDFView/Open
11_references.pdf34.05 kBAdobe PDFView/Open
12_publications.pdf7.62 kBAdobe PDFView/Open
13_vitae.pdf6.53 kBAdobe PDFView/Open

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