Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/239440
Title: ANTIDIABETIC EFFECT OF Macrotyloma uniflorum Lam Verdc LEAVES ON STREPTOZOTOCIN NICOTINAMIDE INDUCED DIABETIC RATS WITH SPECIAL REFERENCE TO ADIPONECTIN
Researcher: Priyanga S
Guide(s): Devaki K
Keywords: Life Sciences,Biology and Biochemistry,Biochemistry and Molecular Biology
University: Karpagam University
Completed Date: 
Abstract: The present observation provide evidence that ethanolic leaf extract of M. uniflorum exhibited antidiabetic activity on streptozotocin-nicotinamide induced diabetic rats. This was due to the enhancement of peripheral utilization of glucose by correcting the impaired liver glycolysis and suppression of its gluconeogenic activity similar to insulin. This positive effect may be due to the presence of alkaloids, flavanoids, terpenoids, saponins, glycosides and other constituents present in the leaves which could act synergically or independently restore the carbohydrate metabolising enzymes and alleviate oxidative stress by enhancing the antioxidant system. The isolated compounds from M. uniflorum were able to up regulate the mRNA expression of adiponectin. Although the mechanism underlying this regulation is unclear, this research supports the inclusion of this plant in traditional antidiabetic preparations and the isolated compounds from M. uniflorum could serve as better candidates for the development of antidiabetic formulations. newline
Pagination: 
URI: http://hdl.handle.net/10603/239440
Appears in Departments:Biochemistry

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05_chapter 1_introduction.pdf606.41 kBAdobe PDFView/Open
06_chapter 2.pdf2.19 MBAdobe PDFView/Open
07_chapter 3.pdf3.84 MBAdobe PDFView/Open
08_chapter 4.pdf5.9 MBAdobe PDFView/Open
09_chapter 5.pdf171.4 kBAdobe PDFView/Open
10_references.pdf396.2 kBAdobe PDFView/Open
11_publications.pdf11.87 kBAdobe PDFView/Open


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