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Title: Synthesis Characterization and Biological Evaluation of Coumarin_1_2_4_Oxadiazoles_ Styryl_Furo_Chromen_Methanones and Pyrazolo_Quinoline_Trione Based Heterocyclic Compounds
Researcher: B Srinivas
Guide(s): Koya Prabhakara Rao
University: Vignans Foundation for Science Technology and Research
Completed Date: 2019
Abstract: Heterocyclic compounds are highly important class of organic compounds due newlineto large number of applications such as pharmaceutical, biological, agrochemical, newlineindustrial, biotechnology, and material chemistry. In fact, the major pharmaceuticals, newlinebiologically active and agrochemicals are heterocyclic compounds. Large and variety newlineof heterocyclic compounds are reported in the literature so far. The importance due to newlinethe design and the synthesis of heterocyclic chemistry is increasing rapidly day by day newlinein synthetic and medicinal organic chemistry. The heterocyclic chemistry is recognized newlineas an important discipline of general significance that hit the major aspects of recent newlinechemical science, medicine, and organic chemistry. In the heterocyclic chemistry newlinevarious structural motifs of the molecules provided pharmacological and biological newlineactivities to compounds. The Oxadiazoles motif is one of such significant heterocyclic newlinemotif, which play an important role in bio-isosteric and metabolically stable newlinemolecules, a replacement for the associate organic molecular unit. newlineIndeed, 1,2,4-oxadiazoles have received tidy attention in the pharmaceutical newlineindustry as heterocyclic drug moieties. They have been utilized within the style of newlinediverse biologically active templates like muscarinic agonists, trypsin enzyme newlineinhibitors, opposed inflammatory agents, aminoalkane H3 antagonists, anticancer newlineagents, and MAO inhibitors. Moreover, the derivative of chromene moiety leads to a newlinewide range of biological activities due to their interactive nature with various protein newlinemoieties. Benzopyran derivatives are also exhibit important biological activities such newlineas anticancer, antioxidant and antimicrobial activity etc. Furan and its derivatives newlineexhibit biological activity such as in the defense system. They find applications as newlineoxidants, antioxidants, as brightening agents, for drugs and in other fields of newlinemedicinal and agrochemistry.
Pagination: 147
Appears in Departments:Division of Chemistry

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