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Title: Identification and characterization of anti hiv activity from marine bivalves
Researcher: ShettyRavi Dyavar
Guide(s): Debashis, Mitra
Keywords: Biotechnology
Cell Science
Upload Date: 25-Aug-2011
University: University of Pune
Completed Date: September 2007
Abstract: Human Immuno Deficiency Virus type 1 (HIV-1) is the causative agent of Acquired Immuno Deficiency Syndrome (AIDS). HIV-1 mainly infects body T cells and macrophages. The loss of T cells during the viral infection leads to the weakened immune system. Feeble immune response of the immune system provides opportunity to establish different microbial infections in infected patients. The decrease in number of T cells, heavy viral load and damaging effect of opportunistic infections in patients leads to the death of infected persons. After identification of AIDS virus in 1980s, several approaches were developed to target both viral proteins and cellular proteins involved in HIV-1 replication. Most of the strategies target viral proteins like reverse transcriptase, protease, integrase, Tat, Rev, Nef, gp120 and gp41 etc. and also cellular proteins that are involved in viral entry, integration, transcription and maturation of viral life cycle. Although the currently available drugs reduces the viral load remarkably but fails to treat infected patients completely because of drug toxicities, generation of drug resistant mutant variants, existence of latent viral reservoirs and defective immune responses during the therapy. New inhibitors of viral replication are strongly required with novel mechanism of action and potent inhibitory effect.
Pagination: 170p.
Appears in Departments:National Centre for Cell Science

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01_title.pdf40.82 kBAdobe PDFView/Open
02_certificate.pdf86.3 kBAdobe PDFView/Open
03_declaration.pdf87.25 kBAdobe PDFView/Open
04_contents.pdf118.83 kBAdobe PDFView/Open
05_acknowledgements.pdf76.6 kBAdobe PDFView/Open
06_abbreviations.pdf122.03 kBAdobe PDFView/Open
07_abstract.pdf124.16 kBAdobe PDFView/Open
08_dedication.pdf89.99 kBAdobe PDFView/Open
09_chapter1.pdf1.26 MBAdobe PDFView/Open
10_chapter2.pdf280.42 kBAdobe PDFView/Open
11_chapter3.pdf633.19 kBAdobe PDFView/Open
12_chapter4.pdf209.31 kBAdobe PDFView/Open
13_chapter5.pdf297.19 kBAdobe PDFView/Open
14_list of publications and presentations.pdf113.71 kBAdobe PDFView/Open
15_Brief Articles.pdf593.51 kBAdobe PDFView/Open

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