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Title: Novel Synthetic and Biological Studies on Benzothiazoles_ Benzimidazoles Oxazolidinones and Pyrazolopyrimidine
Guide(s): Mandava Venkata Basaveswara Rao, D.Nagaraju
University: Vignans Foundation for Science Technology and Research
Completed Date: 2017
Abstract: Heterocyclic compounds are important building blocks used to build up compounds of biological or medicinal chemistry interest to chemists. A huge number of heterocyclic building blocks have applications in pharmaceutical research, agriculture, and drug discovery. Keeping in view of the importance of the hetero cyclic ring containing compounds, in the present thesis describes the synthetic and biological studies on some of the important category of drug substances particularly Benzothiazole , Benzimidazole ,oxazolidinones and pyrazolopyrimidine containing hetero cyclic ring. Here the thesis containing research work on novel benzothiazole scaffolds , new synthetic method for the preparation of benzimidazole has been developed using a new catalyst Gd (OTf) 3 under microwave irradiation, C-ring modified and C-5 Substituted new oxazolidino amide/sulfonamides conjugates and the ultrasound assisted synthesis of a series of 2- alkynyl pyrazolo[1,5-a] pyrimidine derivatives . The total work carried out in the present research programme is being presented in six chapters. newline
Appears in Departments:Division of Chemistry

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10_summery.pdfAttached File1.62 MBAdobe PDFView/Open
11_publications.pdf604.84 kBAdobe PDFView/Open
1_title.pdf204.87 kBAdobe PDFView/Open
2_certificate.pdf301.17 kBAdobe PDFView/Open
3_preliminary pages.pdf673.1 kBAdobe PDFView/Open
4_chapter-1.pdf905.6 kBAdobe PDFView/Open
5_chapter-2.pdf1.04 MBAdobe PDFView/Open
6_chapter-3.pdf1.5 MBAdobe PDFView/Open
7_chapter-4.pdf1.17 MBAdobe PDFView/Open
8_chapter-5.pdf1.46 MBAdobe PDFView/Open
9_chapter-6.pdf982.56 kBAdobe PDFView/Open

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